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RENEWAL: Regulation of vascular smooth muscle cell apoptosis and cell senescence in atherosclerosis

Amount: £1,618,000
Funding type: research
Funder scheme: Programme Grants
Investigator: M R Bennett
Institution: University of Cambridge
Funded outputs count: 41
Funder award ID: RG/08/009/25841
OpenAlex ID: G1644971646
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
2021 · Matthew D. Worssam, Helle F. Jørgensen · Biochemical Society Transactions · 44
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Cardiovascular ACE2 Receptor Expression in Patients Undergoing Heart Transplantation
2021 · Johannes Bargehr, Patrick Rericha, et al. · ESC Heart Failure · 14
Efficacy and limitations of senolysis in atherosclerosis
2021 · Abel Martin Garrido, Anuradha Kaistha, et al. · Cardiovascular Research · 83
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Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
2021 · Anna K. Uryga, Mandy O. J. Grootaert, et al. · Communications Biology · 73
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DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
2021 · Ana Quiles-Jiménez, Ida Gregersen, et al. · Atherosclerosis · 19
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Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
2021 · Mandy O J Grootaert, Martin R Bennett · Cardiovascular Research · 512
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis
2020 · Mandy O.J. Grootaert, Alison Finigan, et al. · Circulation Research · 253
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Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors
2020 · Julie N.E. Chan, Melanie Humphry, et al. · European Journal of Immunology · 14
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The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis
2016 · Yuh Fen Pung, William M. Chilian, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2
DNA Damage and Repair in Vascular Disease
2015 · Anna Uryga, Kelly Gray, et al. · Annual Review of Physiology · 82
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Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability
2015 · Julie Wang, Anna K. Uryga, et al. · Circulation · 350
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Ageing induced vascular smooth muscle cell senescence in atherosclerosis
2015 · Anna K. Uryga, Martin R. Bennett · The Journal of Physiology · 160
Akt isoforms in vascular disease
2015 · Haixiang Yu, Trevor Littlewood, et al. · Vascular Pharmacology · 107
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Myocardin Regulates Vascular Smooth Muscle Cell Inflammatory Activation and Disease
2015 · Matthew Ackers-Johnson, Amarnath Talasila, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 128
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Quantification of Apoptosis in Mouse Atherosclerotic Lesions
2015 · Nichola L. Figg, Martin R. Bennett · Methods in molecular biology · 5
Effects of DNA Damage in Smooth Muscle Cells in Atherosclerosis
2014 · Kelly Gray, Sheetal Kumar, et al. · Circulation Research · 112
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Akt1 Regulates Vascular Smooth Muscle Cell Apoptosis Through FoxO3a and Apaf1 and Protects Against Arterial Remodeling and Atherosclerosis
2014 · Joanna Tucka, Haixiang Yu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 72
Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans
2013 · Emma Yu, Patrick A. Calvert, et al. · Circulation · 283
Myocardin Regulates Vascular Response to Injury Through miR-24/-29a and Platelet-Derived Growth Factor Receptor-β
2013 · Amarnath Talasila, Haixiang Yu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 51
Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation
2013 · Yue Zheng, Melanie Humphry, et al. · Immunity · 205
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Vascular Smooth Muscle Cell Sirtuin 1 Protects Against DNA Damage and Inhibits Atherosclerosis
2012 · Isabelle Gorenne, Sheetal Kumar, et al. · Circulation · 271
The Methyl Xanthine Caffeine Inhibits DNA Damage Signaling and Reactive Species and Reduces Atherosclerosis in ApoE −/− Mice
2012 · John R. Mercer, Kelly Gray, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 29
Aging and Atherosclerosis
2012 · Julie C. Wang, Martin Bennett · Circulation Research · 957
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Mitochondria in vascular disease
2012 · E. Yu, J. Mercer, et al. · Cardiovascular Research · 153
Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base‐excision repair enzyme OGG1
2012 · Lee Siggens, Nichola Figg, et al. · The FASEB Journal · 60
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