Integrative Network Modeling of Cognitive Resilience to Alzheimer's Disease
Description: This proposal aims to systematically develop and validate molecular network models underlying cognitive resilience to AD risk. We will generate and analyze an AD-resilient dataset comprised of genetic, transcriptomic and proteomic data from a large number of very old and AD-resilient human brains and build network models of cognitive resilience to AD that will be extensively validated in C. elegans and mouse models of AD.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2017-09-15
End date: 2024-05-31
Investigator: MICHELLE E EHRLICH
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 82
Funder award ID: R01AG057907
OpenAlex ID: G1331733804