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TRAJECTOME - Stratifikation von Depressions-Trajektorien basierend auf zeitlichen Krankenverläufen und Multimorbidität: zur quantitativen Untersuchung von Patiententrajektorien und Vorhersage von Multi-Target-Medikamentenkandidaten

Amount: €325,300
Funding type: grant
Funder scheme: Individualisierte Medizin
Start date: 2020-05-01
End date: 2023-08-31
Institution: Universitätsmedizin Greifswald
Funded outputs count: 16
Funder award ID: 01KU2004
OpenAlex ID: G1656323759
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
2026 · Nora I. Strom, Brad Verhulst, et al. · Nature Genetics · 32
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Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories
2024 · Andras Gezsi, Sandra Van der Auwera, et al. · Nature Communications · 22
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RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening
2024 · Shrestha Ghosh, Mileena T. Nguyen, et al. · Nature Communications · 9
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Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
2024 · Nora I. Strom, Brad Verhulst, et al. · medRxiv · 27
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Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters
2024 · Sarah Bonk, Nora Eszlari, et al. · Journal of Affective Disorders · 6
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Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes
2024 · Sandra Van der Auwera, Sabine Ameling, et al. · International Journal of Molecular Sciences · 15
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Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population
2023 · Kevin Kirchner, Linda Garvert, et al. · International Journal of Molecular Sciences · 5
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TREML2 Gene Expression and Its Missense Variant rs3747742 Associate with White Matter Hyperintensity Volume and Alzheimer’s Disease-Related Brain Atrophy in the General Population
2022 · Annemarie Luise Kühn, Stefan Frenzel, et al. · International Journal of Molecular Sciences · 4
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Association of spermidine plasma levels with brain aging in a population‐based study
2022 · Silke M. Wortha, Stefan Frenzel, et al. · Alzheimer s & Dementia · 25
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Vitamin D deficit is associated with accelerated brain aging in the general population
2022 · Jan Terock, Sarah Bonk, et al. · Psychiatry Research Neuroimaging · 15
Genome-wide gene-gene interaction of the 5-HTTLPR promoter polymorphism emphasizes the important role of neuroplasticity in depression
2022 · Linda Garvert, Kevin Kirchner, et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 3
APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses
2022 · Sarah Bonk, Kevin Kirchner, et al. · Biomedicines · 9
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The interplay between genetic variation and gene expression of the glucocorticoid receptor gene NR3C1 and blood cortisol levels on verbal memory and hippocampal volumes
2022 · Sandra Van der Auwera, Johanna Klinger-König, et al. · European Archives of Psychiatry and Clinical Neuroscience · 6
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Plasma circulating micro-RNAs associated with alexithymia reflect a high overlap on neuropsychiatric outcomes
2022 · Sandra Van der Auwera, Sabine Ameling, et al. · Journal of Affective Disorders · 7
The Impact of Resilience, Alexithymia and Subjectively Perceived Helplessness of Myocardial Infarction on the Risk of Posttraumatic Stress
2022 · Kevin Kirchner, Hartmut Brauer, et al. · Journal of Clinical Psychology in Medical Settings · 16
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Association between different dimensions of childhood traumatization and plasma micro-RNA levels in a clinical psychiatric sample
2021 · Sandra Van der Auwera, Sabine Ameling, et al. · Journal of Psychiatric Research · 6
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