Mitochondrial action of metformin in aging and longevity
Description: The oral medication metformin is best known for its ability to treat diabetes, but more recently it has been found to have many additional health benefits such as inhibiting cancer growth and extending lifespan. Despite these well described effects, the ways that metformin promotes healthy aging and extends lifespan remain unknown. This project will determine the mechanisms by which metformin produces benefits on longevity with a focus on the drug’s effects on the cell’s powerhouse, the mitochondria, with the ultimate goal of exploiting metformin action to promote healthy aging in humans.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-09-15
End date: 2025-05-31
Investigator: ALEXANDER A SOUKAS
Institution: MASSACHUSETTS GENERAL HOSPITAL
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 15
Funder award ID: R01AG069677
OpenAlex ID: G8724328665