Mitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing Loss
Description: PUBLIC HEALTH RELEVANCE: Reducing caloric intake extends the lifespan of a variety of species and delays the progression of age- associated diseases such as age-related hearing loss (AHL) (1-9), a common feature of aging that affects more than 40% of people over 65 years of age in the US (13). The overall goal of our research proposal is to provide new basic knowledge of the mechanism underlying the efficacy of CR - the most reproducible intervention for increasing lifespan in mammals - to delay the development of AHL in mammals. The results of our proposal will provide an enhanced understanding of the fundamental mechanisms underlying AHL, and the opportunity to identify interventions that will delay presbycusis in humans.
Funding type: research
Funder scheme: R01
Start date: 2013-07-01
End date: 2019-06-30
Investigator: SHINICHI SOMEYA
Institution: UNIVERSITY OF FLORIDA
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 37
Funder award ID: R01DC012552
OpenAlex ID: G7985573621