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Exploring irisin as a novel target for Alzheimer's Disease

Description: PUBLIC HEALTH RELEVANCE Neurological impairment caused Alzheimer’s Disease and the associated dementia ever increasing health burden. Exercise has been shown in animal models and clinical studies in humans to be neuroprotective in Alzheimer’s Disease. Exploiting the molecular mediators of these neuroprotective effects is a promising way to generate novel therapeutic targets.
Funding type: research
Funder scheme: R21
Start date: 2019-05-01
End date: 2021-08-31
Investigator: SE HOON CHOI
Institution: MASSACHUSETTS GENERAL HOSPITAL
Field: Medicine
Funded outputs count: 6
Funder award ID: R21AG062904
OpenAlex ID: G8932985319
Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice
2026 · Simone M. Mellert, Joana F. da Rocha, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis
2026 · Sina C. Rosenkranz, Joana F. da Rocha, et al. · Nature Metabolism · 6
Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
2025 · Joana F. da Rocha, Michelle L. Lance, et al. · Nature Neuroscience · 19
Effects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial
2024 · An Ouyang, Can Zhang, et al. · Life · 11
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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
2023 · Eunhee Kim, Hyeonwoo Kim, et al. · Neuron · 133
Exercise hormone irisin is a critical regulator of cognitive function
2021 · Mohammad R. Islam, Sophia Valaris, et al. · Nature Metabolism · 423
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