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Restoring Blood-Brain Function to Improve Cognition in Alzheimer's Disease

Description: The proposed research is relevant to public health because it is expected to advance understanding of blood- brain barrier function in neurodegenerative diseases and potentially establish a novel disease-modifying treatment strategy for Alzheimer's disease. Thus, the proposed research is relevant to the mission of the NIH/NIA, which is to develop fundamental knowledge that will help reduce the burden of human illness including diseases and conditions related to the aging process.
Funding type: research
Funder scheme: RF1
Start date: 2011-09-01
End date: 2023-08-31
Investigator: ANIKA M.S. HARTZ
Institution: UNIVERSITY OF KENTUCKY
Subfield: Neurology
Funded outputs count: 20
Funder award ID: RF1AG039621
OpenAlex ID: G7589908415
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
2022 · Geetika Nehra, Bjoern Bauer, et al. · Pharmacology & Therapeutics · 127
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Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model
2021 · Yujie Ding, Yu Zhong, et al. · Fluids and Barriers of the CNS · 35
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Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis
2021 · Lucille M. Yanckello, Jared D. Hoffman, et al. · Nutritional Neuroscience · 27
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
2021 · Shon A. Koren, Matthew J. Hamm, et al. · International Journal of Molecular Sciences · 13
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New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models
2020 · Amanda B. Chai, Anika M. S. Hartz, et al. · International Journal of Molecular Sciences · 50
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Brain arteriolosclerosis
2020 · Brittney L. Blevins, Harry V. Vinters, et al. · Acta Neuropathologica · 203
Mamma Mia, P‐glycoprotein binds again
2020 · Richard Callaghan, Ingrid C. Gelissen, et al. · FEBS Letters · 12
David S. Miller: Scientist, Mentor, Friend—a tribute and thank you
2020 · Björn Bauer, J. Larry Renfro, et al. · Fluids and Barriers of the CNS
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APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease
2020 · Ai-Ling Lin, Ishita Parikh, et al. · Neurobiology of Disease · 45
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The Blood-Brain Barrier in Alzheimer’s Disease
2020 · Steffen E. Storck, Anika M. S. Hartz, et al. · Handbook of experimental pharmacology · 33
Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
2018 · Anika M.S. Hartz, Julia A. Schulz, et al. · Journal of Visualized Experiments · 33
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
2018 · Steffen E. Storck, Anika M.S. Hartz, et al. · Brain Behavior and Immunity · 144
Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer’s Disease Mouse Model
2018 · Anika M. S. Hartz, Yu Zhong, et al. · Frontiers in Aging Neuroscience · 54
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Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
2018 · David Ma, Amy C. Wang, et al. · Scientific Reports · 300
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Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions
2016 · Ishita Parikh, Janet Guo, et al. · Aging · 82
Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
2016 · Ralf G Rempe, Anika MS Hartz, et al. · Journal of Cerebral Blood Flow & Metabolism · 786
Aβ40 Reduces P-Glycoprotein at the Blood–Brain Barrier through the Ubiquitin–Proteasome Pathway
2016 · Anika M.S. Hartz, Yu Zhong, et al. · Journal of Neuroscience · 98
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
2015 · Begum G. Akkaya, Joseph K. Zolnerciks, et al. · Molecular Membrane Biology · 33
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ABC Transporters and the Alzheimer’s Disease Enigma
2012 · Andrea Wolf, Björn Bauer, et al. · Frontiers in Psychiatry · 103
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Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
2011 · Anika M.S. Hartz, Björn Bauer, et al. · Stroke · 248
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