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R01DK115398

Funded outputs count: 19
Funder award ID: R01DK115398
OpenAlex ID: G169139346
A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology
2025 · Yingying Zhang, Alden K. Leung, et al. · Nature Communications · 4
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Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants
2023 · You Chen, Mauricio I. Paramo, et al. · Annual Review of Genetics · 2
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Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations
2023 · Dapeng Xiong, Yunguang Qiu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 4
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A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
2022 · Yadi Zhou, Yuan Liu, et al. · Nature Biotechnology · 203
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Functional genomic assays to annotate enhancer–promoter interactions genome wide
2022 · Alden King-Yung Leung, Li Yao, et al. · Human Molecular Genetics · 9
Advancing discovery of risk-altering variants for complex diseases by functionally informed fine-mapping
2022 · You Chen, Andrew G. Clark, et al. · Neuron · 1
A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers
2022 · Li Yao, Jin Liang, et al. · Nature Biotechnology · 89
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Implications of disease-related mutations at protein–protein interfaces
2021 · Dapeng Xiong, Dongjin Lee, et al. · Current Opinion in Structural Biology · 38
A 3D structural SARS-CoV-2–human interactome to explore genetic and drug perturbations
2021 · Shayne D. Wierbowski, Siqi Liang, et al. · Nature Methods · 31
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Progress in methodologies and quality‐control strategies in protein cross‐linking mass spectrometry
2021 · Kumar Yugandhar, Qiuye Zhao, et al. · PROTEOMICS · 8
De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types
2020 · Siwei Chen, Jiebiao Wang, et al. · Molecular Autism · 31
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Structure-based validation can drastically underestimate error rate in proteome-wide cross-linking mass spectrometry studies
2020 · Kumar Yugandhar, Ting-Yi Wang, et al. · Nature Methods · 30
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Transcription imparts architecture, function and logic to enhancer units
2020 · Nathaniel D. Tippens, Jin Liang, et al. · Nature Genetics · 103
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A massively parallel barcoded sequencing pipeline enables generation of the first ORFeome and interactome map for rice
2020 · Shayne D. Wierbowski, Tommy V. Vo, et al. · Proceedings of the National Academy of Sciences · 19
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Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
2019 · Robert Fragoza, Jishnu Das, et al. · Nature Communications · 70
Leveraging genetic interactions for adverse drug-drug interaction prediction
2019 · Sheng Qian, Siqi Liang, et al. · PLoS Computational Biology · 40
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Inferring Protein-Protein Interaction Networks From Mass Spectrometry-Based Proteomic Approaches: A Mini-Review
2019 · Kumar Yugandhar, Shagun Gupta, et al. · Computational and Structural Biotechnology Journal · 51
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