Melatonin suppresses ovarian follicle atresia and increases the number of growing follicles.
Description: The present study was undertaken to examine whether melatonin treatment suppresses ovarian follicle atresia and increases the number of growing follicles. Female ICR mice (10 weeks old) were supplemented with melatonin for 4 weeks. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological and transcriptome analysis. The number of secondary follicles in ovary was increased in melatonin group compared with control group. The fertilization rate and blastocyst rate were higher in melatonin group. The genes relevant to activation of primordial follicles and follicle growth were extracted in melatonin group by genome wide gene analysis using microarray. Melatonin may reduce follicle atresia and accelerate follicle growth by its multiple actions.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Hiroshi TAMURA
Institution: Yamaguchi University
Funded outputs count: 9
Funder award ID: 16K11091
OpenAlex ID: G1710207103