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Biological Underpinnings of Socioeconomic Differentials in Health and Mortality

Description: Project Narrative This research will provide novel information about how socioeconomic status “gets under the skin” to produce differential health and mortality. It will provide information about biological mechanisms associated with adverse socioeconomic circumstances that are also linked to poor health and mortality. These include a wide range of physiological indicators, immune system functioning, epigenetic, molecular and cellular indicators.
Funding type: research
Funder scheme: R01
Start date: 2018-09-01
End date: 2025-06-30
Investigator: EILEEN M CRIMMINS
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Funded outputs count: 108
Funder award ID: R01AG060110
OpenAlex ID: G1170649370
When to Trust Epigenetic Clocks: Avoiding False Positives in Aging Interventions
2026 · Daniel S. Borrus, Raghav Sehgal, et al. · Aging Cell · 12
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Finding the turning point in aging: a comparison of physical, cognitive, and psychological trajectories among centenarians and non-centenarians
2026 · Erfei Zhao, Jennifer A Ailshire, et al. · The Journals of Gerontology Series A
Biomarkers help us understand how cellular and systemic aging contribute to mortality: a study utilizing a machine-learning approach in the Health and Retirement Study
2026 · Eric T Klopack, Eileen M Crimmins · The Journals of Gerontology Series A · 2
Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations
2026 · Songmi Lee, Clint L. Miller, et al. · Human Genetics and Genomics Advances · 1
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Cognitive Decline and Dementia Trajectories by Dizziness Status in Older Adults
2025 · Jung Ki Kim, Eileen M. Crimmins · Journal of Applied Gerontology · 2
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
2025 · Qiao Wu, Eric T. Klopack, et al. · Nature Communications · 9
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A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (Inflammation Latent Variable Methylation Surrogate, InfLaMeS)
2025 · Helen C S Meier, Eric T Klopack, et al. · The Journals of Gerontology Series A · 2
Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems
2025 · Raghav Sehgal, Yaroslav Markov, et al. · Nature Aging · 107
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Living in historically redlined neighborhoods and biological aging among older adults
2025 · Calley E Fisk, Katrina M Walsemann, et al. · The Journals of Gerontology Series A
Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults
2025 · Thalida Em Arpawong, Belinda Hernandez, et al. · GeroScience · 7
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Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable
2025 · Eileen M. Crimmins · Demography · 3
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Increasing Educational Inequality in Biological Aging Among U.S. Adults Aged 50–79 From 1988–1994 to 2015–2018
2025 · Mateo P. Farina, Jung Ki Kim, et al. · Demography · 2
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Using machine-learning to identify differences in the association between blood-based biomarkers and later life health across race and ethnicity
2025 · Mateo P Farina, Eric T Klopack, et al. · The Journals of Gerontology Series A · 1
Aging measures and cancer in the Health and Retirement Study (HRS)
2025 · Shuo Wang, Anna Prizment, et al. · Nature Communications · 13
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Does the southern health disadvantage extend to accelerated biological aging: evidence from the health and retirement study
2025 · Addam Reynolds, Mateo P Farina, et al. · The Journals of Gerontology Series B · 2
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
2025 · Eric T. Klopack, Gokul Seshadri, et al. · Aging · 4
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Physical Activity Is Associated With Decreased Epigenetic Aging: Findings From the Health and Retirement Study
2025 · Farah Ammous, Mark D. Peterson, et al. · Journal of Cachexia Sarcopenia and Muscle · 26
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Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries
2025 · Eric T. Klopack, Belinda Hernandez, et al. · Social Science & Medicine · 1
Health impact of a hypothetical intervention on immune burden of cytomegalovirus (CMV) among older adults in the US: a prospective analysis of the Health and Retirement Study Cohort
2025 · Yuelin He, Jessica Faul, et al. · The Lancet Regional Health - Americas
How much can biomarkers explain sociodemographic inequalities in cognitive dysfunction and cognitive impairment? Results from a machine learning model in the Health and Retirement Study
2025 · Eric T Klopack, Mateo P Farina, et al. · Journal of Alzheimer s Disease · 3
The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study
2025 · Kristina Van Dang, Eun Young Choi, et al. · The Journals of Gerontology Series A · 7
Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults
2025 · Lauren A. Opsasnick, Wei Zhao, et al. · Brain Behavior & Immunity - Health
Sex variation in the relationship between APOE ε4, cognitive decline, and dementia
2025 · Eleanor M. Kerr, Jennifer A. Ailshire, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
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Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults
2025 · Lauren L Schmitz, Lauren A Opsasnick, et al. · PNAS Nexus · 6
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Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries
2025 · Eileen M Crimmins, Belinda Hernandez, et al. · The Journals of Gerontology Series A · 22
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