Get started
Award

Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity

Description: Public Health Relevance Statement The CAV1 gene encodes the caveolin-1 protein which is associated with glaucoma, the second leading cause of blindness worldwide. The expression of caveolin-1 is also elevated in retinal inflammatory diseases such as diabetic retinopathy and autoimmune uveitis, but the function of caveolin-1 in the retina remains elusive. Understanding the function of this ocular disease-associated gene is likely to lead to novel therapeutic strategies for inflammatory eye disease.
Funding type: research
Funder scheme: R01
Start date: 2009-12-01
End date: 2026-08-31
Investigator: MICHAEL H ELLIOTT
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 40
Funder award ID: R01EY019494
OpenAlex ID: G9000904772
Non-caveolar caveolin - 1 in retinal Müller glia promotes innate immune responses
2026 · Eric N. Enyong, Olawale O. Bankole, et al. · Journal of Biological Chemistry
Comparative analysis of In vivo endothelial cell translatomes across central nervous system vascular beds
2024 · Ana J. Chucair-Elliott, Kevin Pham, et al. · Experimental Eye Research · 3
The effects of time restricted feeding on age-related changes in the mouse retina
2024 · Cade A. Huston, Madison Milan, et al. · Experimental Gerontology · 6
Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium
2024 · Ana J. Chucair-Elliott, Sarah R. Ocañas, et al. · Neurobiology of Aging · 11
Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects
2024 · Lauren R. Miller, Marisa A. Bickel, et al. · GeroScience · 17
PDF
IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
2024 · Lauren R. Miller, Marisa A. Bickel, et al. · Frontiers in Aging Neuroscience · 13
Analysis of Lipids, Fatty Acid, and Cholesterol in Membrane Microdomains
2023 · Martin-Paul Agbaga, Mark E. McClellan, et al. · Methods in molecular biology · 3
PDF
Caveolin-1 in Müller Glia Exists as Heat-Resistant, High Molecular Weight Complexes
2023 · Eric N. Enyong, Jami Gurley, et al. · Advances in experimental medicine and biology · 3
PDF
Translatomic response of retinal Müller glia to acute and chronic stress
2022 · Ana J. Chucair-Elliott, Sarah R. Ocañas, et al. · Neurobiology of Disease · 30
Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease
2022 · Eric N. Enyong, Jami M. Gurley, et al. · Progress in Retinal and Eye Research · 46
Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging
2022 · Lauren R. Miller, Stefano Tarantini, et al. · Frontiers in Aging Neuroscience · 28
PDF
The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation
2021 · Jami M. Gurley, Grzegorz B. Gmyrek, et al. · Cells · 3
PDF
Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
2021 · Ivan Jozic, Beatriz Abdo Abujamra, et al. · Communications Biology · 34
PDF
Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina
2020 · Jami M. Gurley, Grzegorz B. Gmyrek, et al. · Investigative Ophthalmology & Visual Science · 25
An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression
2020 · Christopher M. Schafer, Jami M. Gurley, et al. · Proceedings of the National Academy of Sciences · 27
The Role of Caveolin-1 in Retinal Inflammation
2019 · Jami M. Gurley, Michael H. Elliott · Advances in experimental medicine and biology · 7
Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency
2018 · Alaina M. Reagan, Xiaowu Gu, et al. · Neurobiology of Aging · 23
PDF
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype
2017 · Stefano Tarantini, M Noa Valcarcel-Ares, et al. · The Journals of Gerontology Series A · 164
PDF
Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy
2017 · Dustin R. Masser, Laura Otalora, et al. · Journal of Neurochemistry · 36
Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling
2017 · Suellen D. S. Oliveira, Maricela Castellon, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 59
Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains
2017 · Mark E. McClellan, Michael H. Elliott · Methods in molecular biology
Retinal gene expression responses to aging are sexually divergent.
2017 · Mei Du, Colleen A Mangold, et al. · Europe PMC (PubMed Central) · 38
Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma
2016 · Michael H. Elliott, Nicole E. Ashpole, et al. · Scientific Reports · 88
PDF
Caveolins and caveolae in ocular physiology and pathophysiology
2016 · Xiaowu Gu, Alaina M. Reagan, et al. · Progress in Retinal and Eye Research · 80
Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes
2016 · Jeremy Y. Yu, Mei Du, et al. · Diabetologia · 36
PDF
Year
Topic