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Aging, Western Diet and Physiological Dysfunction: Exercise and Inflammation

Description: Advancing age and consumption of a WD are associated with vascular and metabolic dysfunction and disease. However, it is unknown if the adverse effects of WD become greater with aging, the mechanisms by which this occurs, and if these effects can be prevented by habitual aerobic exercise.

Funder: National Institute on Aging

Funding type: career_development

Funder scheme: K01

Start date: 2009-09-30

End date: 2013-08-31

Investigator: LISA A LESNIEWSKI

Institution: UNIVERSITY OF UTAH

Funded outputs count: 24

Funder award ID: K01AG033196

OpenAlex ID: G5684653874

Aerobic exercise and other healthy lifestyle factors that influence vascular aging

2014 · Jessica R. Santos-Parker, Thomas J. LaRocca, et al. · AJP Advances in Physiology Education · 142

The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction

2014 · Anthony J. Donato, Grant D. Henson, et al. · The Journal of Physiology · 68

Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries

2014 · Douglas R. Seals · Journal of Applied Physiology · 118

Effects of aging and high fat diet on endothelial function in middle cerebral arteries is not additive (1070.11)

2014 · Kelly Reihl, Ashley Walker, et al. · The FASEB Journal

Role of arterial telomere dysfunction in hypertension

2014 · R. Garrett Morgan, Stephen J. Ives, et al. · Journal of Hypertension · 67

Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice

2014 · Grant D. Henson, Ashley E. Walker, et al. · Physiological Reports · 28

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Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries

2013 · Ashley E. Walker, Grant D. Henson, et al. · AGE · 33

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Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

2013 · Anthony J. Donato, Ashley E. Walker, et al. · Aging Cell · 168

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2013 · Richard G. Morgan, Stephen J. Ives, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 115

Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation

2013 · Robert T. Davis, John N. Stabley, et al. · Journal of Applied Physiology · 16

TNF-α impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity

2012 · Anthony J. Donato, Grant D. Henson, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 49

Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism

2012 · Lisa A. Lesniewski, Melanie C. Zigler, et al. · Mechanisms of Ageing and Development · 58

SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans

2011 · Anthony J. Donato, Katherine A. Magerko, et al. · The Journal of Physiology · 269

Aerobic exercise reverses arterial inflammation with aging in mice

2011 · Lisa A. Lesniewski, Jessica R. Durrant, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 140

Voluntary running and caloric restriction reverse cerebrovascular endothelial dysfunction in old mice by restoring nitric oxide bioavailability

2011 · Molly Russell, Anthony J. Donato, et al. · The FASEB Journal

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

2011 · L. A. Lesniewski, J. R. Durrant, et al. · The Journals of Gerontology Series A · 69

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Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

2010 · Andrew G. Edwards, Anthony J. Donato, et al. · Mechanisms of Ageing and Development · 70

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise

2010 · Bradley S. Fleenor, Kurt D. Marshall, et al. · The Journal of Physiology · 210

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Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

2010 · Catarina Rippe, Lisa Lesniewski, et al. · Aging Cell · 157

Habitual exercise and vascular ageing

2009 · Douglas R. Seals, Ashley E. Walker, et al. · The Journal of Physiology · 167

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Role of NFκB in age-related vascular endothelial dysfunction in humans

2009 · Anthony J. Donato, Gary L. Pierce, et al. · Aging · 72

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase

2009 · Jessica R. Durrant, Douglas R. Seals, et al. · The Journal of Physiology · 241

B6D2F1 Mice Are a Suitable Model of Oxidative Stress-Mediated Impaired Endothelium-Dependent Dilation With Aging

2009 · L. A. Lesniewski, M. L. Connell, et al. · The Journals of Gerontology Series A · 88

El teónimo de las inscripciones de Barbarin (Navarra): problemas epigráficos y de interpretación

1992 · Javier Velaza Frías · Dialnet (Universidad de la Rioja) · 2