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Role of Autophagy in Vascular Endothelial Dysfunction with Aging

Description: Aging is associated with the development of vascular endothelial dysfunction, an important predictor of cardiovascular disease, but the mechanisms underlying this process are incompletely understood. One unexplored hypothesis is that impairments in autophagy, an important cellular "housekeeping" process, underlie the development of vascular endothelial dysfunction with aging. This translational research project is designed to assess the role of autophagy in age-related vascular endothelial dysfunction in cells, mice and humans, and it will provide novel and clinically important insight into related mechanisms and potential preventative strategies.

Funder: National Institute on Aging

Funding type: fellowship

Funder scheme: F31

Start date: 2011-04-07

End date: 2013-04-06

Investigator: THOMAS LAROCCA

Institution: UNIVERSITY OF COLORADO

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 10

Funder award ID: F31AG039210

OpenAlex ID: G6418776338

Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice

2017 · Michael J. Pagliassotti, Andrea L. Estrada, et al. · The Journal of Nutritional Biochemistry · 57

Aerobic exercise and other healthy lifestyle factors that influence vascular aging

2014 · Jessica R. Santos-Parker, Thomas J. LaRocca, et al. · AJP Advances in Physiology Education · 141

Mitochondrial quality control and age-associated arterial stiffening

2014 · Thomas J. LaRocca, Christopher M. Hearon, et al. · Experimental Gerontology · 81

You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging

2014 · Douglas R. Seals, Rachelle E. Kaplon, et al. · Physiology · 138

2014 · M.J. Pagliassotti, T.J. LaRocca, et al. · The FASEB Journal

Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice

2014 · Rachel A. Gioscia‐Ryan, Thomas J. LaRocca, et al. · The Journal of Physiology · 263

The autophagy enhancer spermidine reverses arterial aging

2013 · Thomas J. LaRocca, Rachel A. Gioscia-Ryan, et al. · Mechanisms of Ageing and Development · 207

Translational evidence that impaired autophagy contributes to arterial ageing

2012 · Thomas J. LaRocca, Grant D. Henson, et al. · The Journal of Physiology · 255

Role of Autophagy in Age-Related Vascular Dysfunction

2012 · Thomas J. LaRocca · CU Scholar (University of Colorado Boulder)

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Habitually exercising older men do not demonstrate age‐associated vascular endothelial oxidative stress

2011 · Gary L. Pierce, Anthony J. Donato, et al. · Aging Cell · 122