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Can Senolytics Improve the Aged Response to Viral Infection

Description: PROJECT NARRATIVE The overall hypothesis that we will be addressing in this proposal is that senescent cells play a causal role in the impaired response to influenza infection that is seen with increasing age. To do this, prior to influenza infection we will treat aged mice with senolytic drugs to delete senescent cells and assess immunological and functional outcomes.
Funding type: research
Funder scheme: R21
Start date: 2021-09-01
End date: 2024-05-31
Investigator: LAURA HAYNES
Institution: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
Subfield: Physiology
Field: Medicine
Funded outputs count: 10
Funder award ID: R21AG071292
OpenAlex ID: G11533769
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
2024 · Binsheng Wang, Lichao Wang, et al. · Cell Metabolism · 59
Cellular senescence is a double‐edged sword in regulating aged immune responses to influenza
2024 · Blake L. Torrance, Hunter A. Panier, et al. · Aging Cell · 12
Impact of senolytic treatment on immunity, aging, and disease
2023 · Erica C. Lorenzo, Blake L. Torrance, et al. · Frontiers in Aging · 25
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Human Rotator Cuff Tears Reveal an Age‐Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro
2023 · Benjamin C. Hawthorne, Ian J. Wellington, et al. · Arthroscopy The Journal of Arthroscopic and Related Surgery · 19
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Senolytic treatment with dasatinib and quercetin does not improve overall influenza responses in aged mice
2023 · Blake L. Torrance, Andreia N. Cadar, et al. · Frontiers in Aging · 15
Cellular senescence is a key mediator of lung aging and susceptibility to infection
2022 · Blake L. Torrance, Laura Haynes · Frontiers in Immunology · 29
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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
2022 · Lichao Wang, Binsheng Wang, et al. · Cell Metabolism · 41
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Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
2021 · Erica C. Lorenzo, Blake L. Torrance, et al. · Aging Cell · 41
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo
2021 · Binsheng Wang, Lichao Wang, et al. · Nature Aging · 145
Strategies for targeting senescent cells in human disease
2021 · Nathan S. Gasek, George A. Kuchel, et al. · Nature Aging · 502
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