Kidney-mediated aging process
Description: The purpose of this study was to elucidate the pathophysiology of the deterioration of renal function, which directly affects the metabolism of organs and causes individual aging. The study revealed that in 5/6 nephrectomized rats with chronic kidney disease, which causes polyuria due to reduced renal concentrating ability, or in rats with liver failure due to administration of diethylnitrosamine, reabsorption of water by the kidneys is necessary to maintain body fluid, and that urea is produced and accumulated in the kidneys through catabolism, and that the The metabolic derangement caused by the breakdown of urea production and accumulation in the kidneys leads to hypertension via functional changes in the skin.If we can clarify the whole picture of this mechanism and develop a method to control it in the future, it is assumed that it will be possible to control physical condition in humans.
Amount: ¥17,030,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Akira Nishiyama
Institution: Kagawa University
Funded outputs count: 44
Funder award ID: 18H03191
OpenAlex ID: G17442653