Role of autophagy in normal and transformed hematopoietic stem cells
Description: PUBLIC HEALTH RELEVANCE: Our proposed investigations will yield a comprehensive understanding of how autophagy is used by HSCs to preserve themselves and maintain blood production throughout life. Moreover, they will uncover how corruption of this essential stress-response mechanism in transformed HSCs contributes to the development of myeloid malignancies and resistance to current targeted therapies. Collectively, they will provide unique insights into the mechanisms regulating the survival of normal and leukemic HSCs, and stand to make critical contributions to the identification of molecular targets that could be engaged to destroy therapy-resistant LSCs in human myeloid malignancies.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2014-04-01
End date: 2019-03-31
Investigator: EMMANUELLE PASSEGUE
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 11
Funder award ID: R01CA184014
OpenAlex ID: G2739583553