Quantitating, Targeting, and Phenotyping In Vivo Cellular Senescence in Humans
Description: PROJECT NARRATIVE The targeted removal of cells in a dysfunctional `senescent' state is a promising strategy to improve health and improve many diseases, but reliable `biomarkers' to identify, target, and isolate these cells in humans are lacking. Our work will identify these biomarkers and isolate senescent cells from humans for the first time. We hope that this work will create new ways to treat patients with therapies that selectively remove these dysfunctional cells.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K99
Start date: 2020-05-01
End date: 2022-04-30
Investigator: NATAN BOHDONIVICH BASISTY
Institution: BUCK INSTITUTE FOR RESEARCH ON AGING
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 9
Funder award ID: K99AG065484
OpenAlex ID: G7653014942