Biological determinants of ageing and late life health, and their pharmacological manipulation.
Description: Age is the main risk factor for common, debilitating conditions including cancer, cardiovascular disease and neurodegeneration. Single gene mutations can extend healthy lifespan in laboratory animals. The mechanisms involved are evolutionarily conserved, with genetic and pharmacological inhibition of the nutrient-sensing insulin/insulin-like growth factor/TOR (IIT) signalling network extending healthy lifespan in yeast, nematode worms, fruit flies and mammals. Dietary restriction (DR) also exten ds healthy lifespan in these organisms, at least in part through altered IIT activity. Both reduced IIT activity and DR induce a broad-spectrum improvement in health and protection against pathology during ageing. Thus, amelioration of the ageing process can protect against diseases of ageing. This programme will have three key goals: 1. To discover how reduced activity IIT activity improves health during ageing, through experimental analysis of signalling and effector mechanisms in model orga nisms; 2 To recapitulate and extend improved health during ageing by pharmacological manipulation of key target molecules, both with existing drugs and new probe molecules; 3. To use results generated in 1 and 2, together with population genetic and drug response information from humans, to translate the discoveries into improvement in health of older people.
Funder: Wellcome Trust
Amount: £4,847,000
Funding type: grant
Funder scheme: Physiology in Health and Disease
Start date: 2013-04-03
End date: 2020-08-31
Investigator: Linda Partridge
Institution: University College London
Subfield: Aging
Domain: Life Sciences
Funded outputs count: 95
Funder award ID: 098565
OpenAlex ID: G1768919997