Award

The Hypothalamic Basis of Aging

Description: NARRATIVE The hypothalamus plays a fundamental role in whole-body aging, but the underlying basis and the interventional value remain to be established; thus, this project is to study the aging relevance and anti- neurodegenerative actions as well as the therapeutic significance of hypothalamic extracellular vesicles. Overall, the study represents a major milestone for developing an important strategy and target for aging- associated health problems and especially neurodegeneration and related diseases.
Funding type: research
Funder scheme: R01
Start date: 2008-04-01
End date: 2028-05-31
Investigator: DONGSHENG CAI
Institution: ALBERT EINSTEIN COLLEGE OF MEDICINE
Funded outputs count: 44
Funder award ID: R01AG031774
OpenAlex ID: G9000878261
2021 · Shoeb Ikhlas, Afia Usman, et al. · Life Science Alliance · 21
2021 · Zhouguang Wang, Wenhe Wu, et al. · Nature Aging · 30
2020 · Bin Yu, Yizhe Tang, et al. · Life Science Alliance · 11
2019 · Dongsheng Cai, Sinan Khor · Cell Metabolism · 138
2017 · Yalin Zhang, Min Soo Kim, et al. · Nature · 566
2017 · Sinan Khor, Dongsheng Cai · Clinical Science · 42
2016 · Albert Alé, Yalin Zhang, et al. · American Journal of Physiology-Endocrinology and Metabolism · 14
2016 · Cheng Han, Wenhe Wu, et al. · Journal of Biological Chemistry · 23
2016 · Cheng Han, Matthew W. Rice, et al. · American Journal of Physiology-Endocrinology and Metabolism · 66
2015 · Yumin Zhang, Gang Liu, et al. · Nature Communications · 37
2015 · Min Soo Kim, Jingqi Yan, et al. · Nature Immunology · 41
2014 · Yizhe Tang, Sudarshana Purkayastha, et al. · Trends in Neurosciences · 114
2014 · Juxue Li, Yizhe Tang, et al. · Molecular Metabolism · 42
2013 · Sudarshana Purkayastha, Dongsheng Cai · Reviews in Endocrine and Metabolic Disorders · 36
Year
Topic