Genetic pathways of replicative senescence and its function in tumorigenesis
Description: The proposed studies will greatly advance our understanding of the molecular regulation of senescence and its function in cancer. Such knowledge will have an important impact on not only the development of effective therapies targeting the senescence response and the advancement of clinical benefit utilizing such strategy for cancer treatment, but also the understanding of the relationship between cancer and aging, which is important for achieving prevention or amelioration of age-related debilitation caused by cancer.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2009-07-01
End date: 2015-06-30
Investigator: HONG ZHANG
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 11
Funder award ID: R01CA131210
OpenAlex ID: G4526430440