Award

Telomere length analysis in the CALERIE trial

Description: PROJECT NARRATIVE The proposed project will conduct new telomere length assays of stored biospecimens from the CALERIE trial, the first ever randomized human trial of long-term caloric restriction. We will use new telomere length data to test if caloric restriction slows the rate of cellular aging in humans, and explore putative biological mechanisms. Overall the project will advance efforts to improve mechanistic understanding of how caloric restriction influence telomere length in humans, which could pinpoint new targets for anti-aging therapies.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R03

Start date: 2022-02-01

End date: 2024-06-30

Investigator: IDAN SHALEV

Institution: PENNSYLVANIA STATE UNIVERSITY, THE

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 3