Award

Network-Driven Dynamics of Replicative Aging

Description: Project Narrative Aging is a key factor in many diseases, such as cancer, diabetes, and neurodegenerative diseases. This project aims at integrating computational modeling and innovative measurement technologies to understand the complexity of single-cell aging and the emergent dynamics from the underlying regulatory networks. Computational models developed from this project will advance a quantitative understanding of mechanisms underlying aging dynamics, laying foundations for strategies for mitigating age-related diseases.
Funding type: research
Funder scheme: R01
Start date: 2017-08-01
End date: 2028-02-29
Investigator: NAN HAO
Institution: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Funded outputs count: 24
Funder award ID: R01AG056440
OpenAlex ID: G9000861753
2026 · Qingqing Liu, Seungmin Yoo, et al. · Molecular Cell · 10
2026 · Yajuan Li, Zhiliang Bai, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Gavin Shuyang Ni, Hetian Su, et al. · Biophysical Journal · 3
2025 · Phuc Nguyen, Zahra Mousavi Karimi, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2025 · Naci Oz, Hetian Su, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2025 · Paula Godoy, Nan Hao · Trends in Cell Biology · 5
2024 · Kevin Tsai, Zhen Zhou, et al. · PLoS Computational Biology · 5
2024 · Yuting Liu, Zhen Zhou, et al. · Cell Systems · 15
2023 · Richard O’Laughlin, Quoc Tran, et al. · ACS Synthetic Biology · 6
2023 · Arkady Pikovsky, Lev S. Tsimring · Mathematical Biosciences · 4
2023 · Richard O’Laughlin, Emerald Forrest, et al. · BIO-PROTOCOL · 9
2023 · Elizabeth Stasiowski, Richard O’Laughlin, et al. · BIO-PROTOCOL · 2
2022 · Alan A. Cohen, Luigi Ferrucci, et al. · Nature Aging · 222
2021 · Joonhyuk Choi, Shuhao Wang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 4
2020 · Emily L. Petty, Lorraine Pillus · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 9
2020 · Yang Li, Yanfei Jiang, et al. · Science · 138
2019 · Richard O'Laughlin, Meng Jin, et al. · Translational Medicine of Aging · 25
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