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Tolerance to Vascularized Allografts in Miniswine

Description: RELEVANCE (See instructions): Immune tolerance of transplanted organs would allow patients to avoid long-term immunosuppressive drugs and the complications caused by these drugs. We have developed a large animal model in which tolerance of kidney transplants can be induced reproducibly. Our goal here is to understand the mechanism of tolerance in this model in order to eventually extend the studies to human organ transplants.

Funder: National Institute of Allergy and Infectious Diseases

Funding type: research

Funder scheme: R37

Start date: 1991-04-01

End date: 2017-02-07

Investigator: DAVID H SACHS

Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

Funded outputs count: 18

Funder award ID: R37AI031046

OpenAlex ID: G2873084977

Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation

2017 · David H. Sachs · Annals of the American Thoracic Society · 8

Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation

2016 · M Tasaki, V Villani, et al. · American Journal of Transplantation · 9

Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model

2015 · V. Villani, K. Yamada, et al. · American Journal of Transplantation · 6

Abrogation of Renal Allograft Tolerance in MGH Miniature Swine: The Role of Intra-Graft and Peripheral Factors in Long-Term Tolerance

2014 · J.R. Scalea, M. Okumi, et al. · American Journal of Transplantation · 16

Development of Antidonor Antibody Directed Toward Non–Major Histocompatibility Complex Antigens in Tolerant Animals

2014 · Joseph R. Scalea, Vincenzo Villani, et al. · Transplantation · 5

Evidence for a Gene Controlling the Induction of Transplantation Tolerance

2014 · P.W. Lee, J.S. Hanekamp, et al. · American Journal of Transplantation · 2

Vascularized Composite Allograft Transplant Survival in Miniature Swine

2013 · Curtis L. Cetrulo, Radbeh Torabi, et al. · Transplantation · 11

The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine

2013 · M. Okumi, J.R. Scalea, et al. · American Journal of Transplantation · 18

Tolerogenicity of Donor Major Histocompatibility Complex–Matched Skin Grafts in Previously Tolerant Massachusetts General Hospital Miniature Swine

2012 · Joshua Weiner, Joseph Scalea, et al. · Transplantation · 5

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2012 · 霍丽娟 · 考试周刊

Hepatocyte Growth Factor Sustains T Regulatory Cells and Prolongs the Survival of Kidney Allografts in Major Histocompatibility Complex-Inbred CLAWN-Miniature Swine

2011 · Manei Oku, Masayoshi Okumi, et al. · Transplantation · 16

Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers

2011 · K. Yamada, A. Hirakata, et al. · American Journal of Transplantation · 18

Signal Joint T-Cell Receptor Excision Circle Assay in Miniature Swine

2011 · Prashanth Vallabhajosyula, Aseda Tena, et al. · Transplantation · 6

Beneficial Effects of Perioperative Low-Dose Inhaled Carbon Monoxide on Pulmonary Allograft Survival in MHC-Inbred CLAWN Miniature Swine

2010 · Hisashi Sahara, Akira Shimizu, et al. · Transplantation · 17

Reversal of age-related thymic involution by an LHRH agonist in miniature swine

2010 · Atsushi Hirakata, Masayoshi Okumi, et al. · Transplant Immunology · 16

Cytoplasmic Inheritance of Transplantation Antigens in Animals Produced by Nuclear Transfer

2009 · John S. Hanekamp, Masayoshi Okumi, et al. · Transplantation · 5

Linked Suppression across an MHC-Mismatched Barrier in a Miniature Swine Kidney Transplantation Model

2008 · Adam D Griesemer, John C LaMattina, et al. · The Journal of Immunology · 33

Role of Persistence of Antigen and Indirect Recognition in the Maintenance of Tolerance to Renal Allografts

2008 · Masayoshi Okumi, Jonathan M. Fishbein, et al. · Transplantation · 30