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Moderate alcohol use: risk or protective factor for age-related cognitive decline, mild cognitive impairment, and brain health in aging

Description: NARRATIVE With the burden that aging-related cognitive impairment and dementia places on society, improved knowledge of how modifiable behaviors, such as alcohol use, affect cognitive and brain health in aging has potential for direct public health impact. This study will inform guidelines for alcohol limits to reduce risk of cognitive impairment and enable more individualized guidance on alcohol use based upon health and genetic information.
Funding type: research
Funder scheme: R01
Start date: 2019-04-15
End date: 2023-01-31
Investigator: LINDA KATHLEEN MCEVOY
Institution: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Funded outputs count: 32
Funder award ID: R01AG062483
OpenAlex ID: G8341694821
APOE ε4‐related blood–brain barrier disruption and APOE ε4‐independent microstructural abnormalities in white matter hyperintensities
2026 · Yuki Oi, Qian Shen, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Long COVID-related blood-brain barrier breakdown and microstructure in older adults are modified by sex and Alzheimer’s disease genetic risk
2025 · Emilie T. Reas, Austin Alderson-Myers, et al. · Imaging Neuroscience · 8
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Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins
2025 · Nathan A. Gillespie, Michael C. Neale, et al. · Aging Brain
Blood-brain barrier permeability varies by brain region and APOE4 status and correlates with brain microstructure among high-AD risk groups
2025 · Seraphina K. Solders, Qian Shen, et al. · NeuroImage Clinical · 9
APOE 𝜀4‐related blood–brain barrier breakdown is associated with microstructural abnormalities
2024 · Emilie T. Reas, Seraphina K. Solders, et al. · Alzheimer s & Dementia · 44
Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins
2024 · Nathan A. Gillespie, Michael C. Neale, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status
2024 · Emilie T. Reas, Curtis Triebswetter, et al. · Alzheimer s Research & Therapy · 21
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The heritability of blood‐based biomarkers related to risk of Alzheimer's disease in a population‐based sample of early old‐age men
2023 · Nathan A. Gillespie, Jeremy A. Elman, et al. · Alzheimer s & Dementia · 17
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Neuroimaging-Derived Predicted Brain Age and Alcohol Use Among Community-Dwelling Older Adults
2023 · Makaya Funk-White, David Wing, et al. · American Journal of Geriatric Psychiatry · 11
Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults
2023 · Amaryllis A. Tsiknia, Humberto Parada, et al. · Neurobiology of Aging · 29
Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age
2022 · Tyler Reed Bell, Jeremy A. Elman, et al. · Journal of the International Neuropsychological Society · 18
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The genetic and environmental etiology of blood-based biomarkers related to risk of Alzheimer’s Disease in a population-based sample of early old-age men
2022 · Nathan A. Gillespie, Robert A. Rissman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Cognitive Reserve and Related Constructs: A Unified Framework Across Cognitive and Brain Dimensions of Aging
2022 · William S. Kremen, Jeremy A. Elman, et al. · Frontiers in Aging Neuroscience · 75
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Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
2022 · Linda K. McEvoy, Jaclyn Bergstrom, et al. · Nutrients · 18
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Midlife omega-3 fatty acid intake predicts later life white matter microstructure in an age- andAPOE-dependent manner
2022 · Amaryllis A Tsiknia, Jaclyn Bergstrom, et al. · Cerebral Cortex · 6
Alcohol use and cognitive aging in middle-aged men: The Vietnam Era Twin Study of Aging
2022 · Alexis C. Garduno, Gail A. Laughlin, et al. · Journal of the International Neuropsychological Society · 2
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The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years
2022 · Nathan A. Gillespie, Sean N. Hatton, et al. · Frontiers in Aging Neuroscience · 8
Alcohol use and cognitive performance: a comparison between Greece and the United States
2021 · Makaya Funk-White, Alison A. Moore, et al. · Aging & Mental Health · 5
Associations between MRI-assessed locus coeruleus integrity and cortical gray matter microstructure
2021 · Jeremy A Elman, Olivia K Puckett, et al. · Cerebral Cortex · 25
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Paradoxical cognitive trajectories in men from earlier to later adulthood
2021 · Graham M.L. Eglit, Jeremy A. Elman, et al. · Neurobiology of Aging · 4
Long‐term associations of cigarette smoking in early mid‐life with predicted brain aging from mid‐ to late life
2021 · Nathan Whitsel, Chandra A. Reynolds, et al. · Addiction · 16
The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males
2021 · Nathan A Gillespie, Sean N Hatton, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.
2021 · Mark Sanderson-Cimino, Matthew S. Panizzon, et al. · Neuropsychology · 11
MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction
2021 · Jeremy A. Elman, Olivia K. Puckett, et al. · Alzheimer s & Dementia · 80
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Brain microstructure mediates sex-specific patterns of cognitive aging
2021 · Emilie T. Reas, Donald J. Hagler, et al. · Aging · 11
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