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Molecular Pathogenesis of Apoptosis in Liver Cells

Funding type: program
Funder scheme: P01
Start date: 2001-09-21
End date: 2006-05-31
Investigator: JOHN J LEMASTERS
Institution: UNIVERSITY OF NORTH CAROLINA CHAPEL HILL
Funded outputs count: 38
Funder award ID: P01DK059340
OpenAlex ID: G657676965
Autophagy in Alcohol‐Induced Liver Diseases
2012 · Angela Dolganiuc, Paul G. Thomes, et al. · Alcoholism Clinical and Experimental Research · 101
Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation
2010 · Insil Kim, John J. Lemasters · Antioxidants and Redox Signaling · 193
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Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation
2010 · Insil Kim, John J. Lemasters · American Journal of Physiology-Cell Physiology · 154
Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes
2009 · Sara Rodriguez-Enriquez, Yoichiro Kai, et al. · Autophagy · 115
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Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism
2007 · John J Lemasters · Journal of Gastroenterology and Hepatology · 110
Selective degradation of mitochondria by mitophagy
2007 · Insil Kim, Sara Rodriguez-Enriquez, et al. · Archives of Biochemistry and Biophysics · 1,555
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Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice
2006 · Linda E. Hammond, Craig D. Albright, et al. · Experimental and Molecular Pathology · 32
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Opioid receptor-independent protection of ischemic rat hepatocytes by morphine
2006 · Jae-Sung Kim, John J. Lemasters · Biochemical and Biophysical Research Communications · 13
Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation
2006 · Yosuke Osawa, Ekihiro Seki, et al. · Liver International · 25
Identification of a novel amidase motif in neutral ceramidase
2006 · Sehamuddin Galadari, Bill X. Wu, et al. · Biochemical Journal · 47
Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes
2006 · Sara Rodriguez-Enriquez, Insil Kim, et al. · Autophagy · 330
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Reactive oxygen species, but not Ca2+overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion
2006 · Jae-Sung Kim, Yingai Jin, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 310
Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids
2005 · Mari Kono, Jennifer L. Dreier, et al. · Journal of Biological Chemistry · 159
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver†
2005 · Yosuke Osawa, Yusuf A. Hannun, et al. · Hepatology · 45
Voltage-dependent anion channel (VDAC) as mitochondrial governator—Thinking outside the box
2005 · John J. Lemasters, Ekhson Holmuhamedov · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 434
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Dephosphorylation of the Rieske iron–sulfur protein after induction of the mitochondrial permeability transition
2005 · Lihua He, John J. Lemasters · Biochemical and Biophysical Research Communications · 25
Isolated mouse liver mitochondria are devoid of glucokinase
2005 · Ernesto Bustamante, Peter Pediaditakis, et al. · Biochemical and Biophysical Research Communications · 18
Dying a Thousand Deaths: Redundant Pathways From Different Organelles to Apoptosis and Necrosis
2005 · John J. Lemasters · Gastroenterology · 152
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Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α
2005 · Yosuke Osawa, Hiroshi Uchinami, et al. · Journal of Biological Chemistry · 221
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NF-κB activation in Kupffer cells after partial hepatectomy
2005 · Liu Yang, Scott T. Magness, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 54
A mitochondrial pool of sphingomyelin is involved in TNFα-induced Bax translocation to mitochondria
2005 · Helene BIRBES, Chiara LUBERTO, et al. · Biochemical Journal · 144
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Positively Charged Ceramide Is a Potent Inducer of Mitochondrial Permeabilization
2005 · Sergei A. Novgorodov, Zdzislaw M. Szulc, et al. · Journal of Biological Chemistry · 112
Tumor Necrosis Factor Induces the Loss of Sphingosine Kinase-1 by a Cathepsin B-dependent Mechanism
2005 · Tarek A. Taha, Kazuyuki Kitatani, et al. · Journal of Biological Chemistry · 95
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
2004 · Kazuyoshi Kon, Jae-Sung Kim, et al. · Hepatology · 494
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Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion
2004 · Jae-Sung Kim, Shigetoshi Ohshima, et al. · Free Radical Biology and Medicine · 73
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