KLF10, CD4+ T cells, and transplant arteriopathy
Description: Narrative The main cause of late-graft failure and death in recipients who survive more than one year after cardiac transplantation is arteriosclerosis of the coronary arteries. Activation of T cells play a major role in the development and progression of the inflammatory response in donor hearts, an effect that is less pronounced with increasing age. We have identified novel factors, KLF10 and a microRNA, miR-340, that are inversely associated with increasing age in T cells and our studies indicate that KLF10 is protective in suppressing T cell responses after cardiac transplantation in older recipients. The proposed studies will provide a detailed understanding underlying the role of KLF10 in regulating T cell responses with the goal of developing therapies for the treatment of transplantation arteriosclerosis to improve graft survival.
Funding type: research
Funder scheme: R01
Start date: 2016-12-15
End date: 2020-11-30
Investigator: MARK W FEINBERG
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 49
Funder award ID: R01HL134849
OpenAlex ID: G4769970342