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Glycation of Protein in Diabetes

Funding type: research
Funder scheme: R37
Start date: 1977-08-01
End date: 2012-07-31
Investigator: JOHN WILLIAM BAYNES
Institution: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
Funded outputs count: 22
Funder award ID: R37DK019971
OpenAlex ID: G110939968
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome
2015 · Gerardo G. Piroli, Allison M. Manuel, et al. · Molecular & Cellular Proteomics · 47
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Identification of protein succination as a novel modification of tubulin
2014 · Gerardo G. Piroli, Allison M. Manuel, et al. · Biochemical Journal · 48
The succinated proteome
2013 · Eric D. Merkley, Thomas O. Metz, et al. · Mass Spectrometry Reviews · 84
Adipocyte protein modification by Krebs cycle intermediates and fumarate ester-derived succination
2013 · Allison M. Manuel, Norma Frizzell · Amino Acids · 20
Chelation therapy for the management of diabetic complications: a hypothesis and a proposal for clinical laboratory assessment of metal ion homeostasis in plasma
2013 · Norma Frizzell, John W. Baynes · Clinical Chemistry and Laboratory Medicine (CCLM) · 17
Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity
2012 · Norma Frizzell, Sonia A. Thomas, et al. · Biochemical Journal · 58
Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications
2012 · Ryoji Nagai, David B. Murray, et al. · Diabetes · 219
Tissue Distribution of S‐(2‐Succino)cysteine (2SC), a Biomarker of Mitochondrial Stress in Obesity and Diabetes
2011 · Sonia A. Thomas, Kenneth B. Storey, et al. · Obesity · 46
Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status
2011 · Chiara Bardella, Mona El‐Bahrawy, et al. · The Journal of Pathology · 281
Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats
2010 · Ryoji Nagai, Mime Nagai, et al. · Biochemical and Biophysical Research Communications · 74
Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes
2009 · Norma Frizzell, Mathur Rajesh, et al. · Journal of Biological Chemistry · 99
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Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: In vivo and in vitro studies
2009 · Justin A. MacDonald, Thorsten Degenhardt, et al. · Cryobiology · 14
AGE–modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis
2009 · Per M Humpert, Ivan K Lukic, et al. · Journal of Leukocyte Biology · 25
Cardiac and Renal Function are Progressively Impaired with Aging in Zucker Diabetic Fatty Type II Diabetic Rats
2009 · John Baynes, David B. Murray · Oxidative Medicine and Cellular Longevity · 45
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The Metal Chelators, Trientine and Citrate, Inhibit the Development of Cardiac Pathology in the Zucker Diabetic Rat
2009 · John W. Baynes, David B. Murray · Experimental Diabetes Research · 32
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A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease
2008 · Qibin Zhang, Jennifer M. Ames, et al. · Journal of Proteome Research · 421
Improved Methods for the Enrichment and Analysis of Glycated Peptides
2008 · Qibin Zhang, Athena A. Schepmoes, et al. · Analytical Chemistry · 69
Succination of Proteins by Fumarate
2008 · Matthew Blatnik, Suzanne R. Thorpe, et al. · Annals of the New York Academy of Sciences · 109
Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes
2007 · Matthew Blatnik, Norma Frizzell, et al. · Diabetes · 140
Enrichment and Analysis of Nonenzymatically Glycated Peptides: Boronate Affinity Chromatography Coupled with Electron-Transfer Dissociation Mass Spectrometry
2007 · Qibin Zhang, Ning Tang, et al. · Journal of Proteome Research · 161
Formation of methionine sulfoxide during glycoxidation and lipoxidation of ribonuclease A
2006 · Jonathan W.C. Brock, Jennifer M. Ames, et al. · Archives of Biochemistry and Biophysics · 16
Development of Capture Assays for Different Modifications of Human Low-Density Lipoprotein
2005 · Gabriel Virella, M. Brooks Derrick, et al. · Clinical and Vaccine Immunology · 36
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