Regulation of nuclear envelope assembly and disassembly
Description: The proposed work is relevant to understanding the molecular mechanisms of Emery- Dreifuss muscular dystrophy, a syndrome that affects three tissues including skeletal muscle, tendons and the cardiac conduction system. The proposed investigation of BAF's interactions with chromatin and histone-modifying enzymes are also relevant to understanding why BAF is essential for human immunodeficiency virus type 1 (HIV- 1) to integrate into human chromosomes. The proposed studies of emerin and BAF in cellular responses to DNA damage are relevant to cancer and human aging.
Funding type: research
Funder scheme: R01
Start date: 1994-05-01
End date: 2014-06-30
Investigator: KATHERINE L WILSON
Institution: JOHNS HOPKINS UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 45
Funder award ID: R01GM048646
OpenAlex ID: G8187054577