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Quadrupole-Orbitrap Mass Spectrometer

Description: PROJECT NARRATIVE The proposed mass spectrometer will provide multiple NIH funded investigators with the analytical capabilities to answer challenging questions aimed at the improvement of human health. The instrumentation used to study metabolites and proteins in biomedical samples have undergone a revolutionary leap in performance. These advancements will facilitate new discoveries to improve our understanding of disease at the molecular level.

Funder: National Institutes of Health

Amount: $600,000

Funding type: grant

Funder scheme: S10

Start date: 2017-05-15

End date: 2018-05-14

Investigator: KIRK C HANSEN

Institution: UNIVERSITY OF COLORADO DENVER

Funded outputs count: 54

Funder award ID: 1s10od021641-01a1

OpenAlex ID: G185736499

Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake

2023 · Cara F. Smith, Zachary L. Nikolakis, et al. · BMC Biology · 64

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Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γΔ5 mice drives acute liver injury

2023 · Lauren G. Poole, Lauren R. Schmitt, et al. · Journal of Thrombosis and Haemostasis · 7

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Molecular insight into the specific interactions of the SARS‐Coronavirus ‐2 nucleocapsid with RNA and host protein

2023 · Eunjeong Lee, Jasmina S. Redzic, et al. · Protein Science · 13

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Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs

2023 · Maxwell C. McCabe, Anthony J. Saviola, et al. · Journal of Proteome Research · 62

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Montane Rattlesnakes in México: Venoms of Crotalus tancitarensis and Related Species within the Crotalus intermedius Group

2023 · Emily R. Grabowsky, Anthony J. Saviola, et al. · Toxins · 5

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Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

2023 · Jackie L. McCourt, Kristen M. Stearns-Reider, et al. · Skeletal Muscle · 19

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A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player

2022 · Terry R. Schaid, Ian LaCroix, et al. · The Journal of Trauma: Injury, Infection, and Critical Care · 10

Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

2022 · Ming Pei, Yixuan Amy Pei, et al. · Bioactive Materials · 27

Trauma Induces Intravascular Hemolysis, Exacerbated by Red Blood Cell Transfusion and Associated With Disrupted Arginine–nitric Oxide Metabolism

2022 · Terry R. Schaid, Mitchell J. Cohen, et al. · Shock · 23

Omics Markers of Red Blood Cell Transfusion in Trauma

2022 · Ian S. LaCroix, Mitchell Cohen, et al. · International Journal of Molecular Sciences · 18

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The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia

2022 · Christophe Langouët-Astrié, Kaori Oshima, et al. · Cell Reports · 49

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Myocardial matrix hydrogel acts as a reactive oxygen species scavenger and supports a proliferative microenvironment for cardiomyocytes

2022 · Raymond M. Wang, Joshua M. Mesfin, et al. · Acta Biomaterialia · 32

Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions

2022 · Eunjeong Lee, Jasmina S. Redzic, et al. · Molecules · 5

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Characterization of decellularized left and right ventricular myocardial matrix hydrogels and their effects on cardiac progenitor cells

2022 · Jervaughn D. Hunter, Arielle Hancko, et al. · Journal of Molecular and Cellular Cardiology · 8

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension

2022 · Sue Gu, Claudia Mickael, et al. · Pulmonary Circulation · 16

Taf2 mediates DNA binding of Taf14

2022 · Brianna J. Klein, Jordan T. Feigerle, et al. · Nature Communications · 11

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Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells

2022 · Sarah B. Crist, Travis Nemkov, et al. · Nature Cell Biology · 61

A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo

2022 · Mark H. Murdock, George S. Hussey, et al. · Oncotarget · 2

Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation

2022 · Travis Nemkov, Paul D. Kingsley, et al. · Blood Advances · 14

Proteasome activity modulates amyloid toxicity

2022 · John Galvin, Elizabeth Curran, et al. · FEMS Yeast Research · 2

Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

2021 · Jinxiang Dai, Patrick J. Cimino, et al. · Nature Cancer · 136

Mammary collagen is under reproductive control with implications for breast cancer

2021 · Qiuchen Guo, Duanchen Sun, et al. · Matrix Biology · 33

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

2021 · Aaron Issaian, Ariel Hay, et al. · Haematologica · 80

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Proteome of Stored RBC Membrane and Vesicles from Heterozygous Beta Thalassemia Donors

2021 · Vassilis L. Tzounakas, Alkmini T. Anastasiadi, et al. · International Journal of Molecular Sciences · 21

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Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs

2021 · Zeeshan H. Syedain, Bee Haynie, et al. · Science Translational Medicine · 57