Basic research for molecular mechanisms underlying antiinflammatory and antioxidative effects of molecular hydrogen
Description: We found that molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. Indeed, preadministration of hydrogen-rich water to mice was enough to protect against lipopolysaccharide-induced sepsis and attenuate liver injury. Furthermore, we found that molecular hydrogen attenuates gefitinib-induced exacerbation of acute lung injury in mice through a reduction in oxidative stress and inflammation. Hydrogen-rich water administration also prevents vascular aging of the aorta in LDL receptor-deficient mice.
Amount: ¥17,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Ohsawa Ikuroh
Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Funded outputs count: 16
Funder award ID: 16H03267
OpenAlex ID: G186133437