Get started
Award

activation of mitochondrial calpain augments cardiac injury in aged hearts

Description: Project Narrative: Heart failure frequently occurs in the elderly patients who suffer from a heart attack. Our research is aimed at understanding why heart cells in the elderly patient are more susceptible to injury during heart attacks and how to save the heart cells and reduce subsequent heart failure occurrence in the elderly population. 1
Funding type: research
Funder scheme: R21
Start date: 2017-04-01
End date: 2020-03-31
Investigator: QUN CHEN
Institution: VIRGINIA COMMONWEALTH UNIVERSITY
Subfield: Cell Biology
Funded outputs count: 27
Funder award ID: R21AG054975
OpenAlex ID: G8635317468
Metformin improves cardiac stress tolerance and mitochondrial function during early aging
2026 · Qun Chen, Jeremy Thompson, et al. · Experimental Gerontology
Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids
2023 · Qun Chen, Anna Kovilakath, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 26
PDF
Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion
2022 · Ling Li, Jeremy Thompson, et al. · Scientific Reports · 23
PDF
Cerebral and myocardial mitochondrial injury differ in a rat model of cardiac arrest and cardiopulmonary resuscitation
2021 · Xianfei Ji, Jennifer L. Bradley, et al. · Biomedicine & Pharmacotherapy · 10
PDF
Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function
2021 · Qun Chen, Jeremy Thompson, et al. · Aging · 45
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart
2020 · Jeremy Thompson, Michael Maceyka, et al. · Mechanisms of Ageing and Development · 30
Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site
2020 · Jakob C. Green, Yuqi Jiang, et al. · Journal of Medicinal Chemistry · 11
Cardiomyocyte specific deletion of p53 decreases cell injury during ischemia-reperfusion: Role of Mitochondria
2020 · Qun Chen, Jeremy Thompson, et al. · Free Radical Biology and Medicine · 19
Endoplasmic reticulum stress-mediated mitochondrial dysfunction in aged hearts
2020 · Qun Chen, Arun Samidurai, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 80
PDF
Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload
2020 · Ahmed A. Mohsin, Jeremy Thompson, et al. · Archives of Biochemistry and Biophysics · 54
Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion
2019 · Qun Chen, Jeremy Thompson, et al. · American Journal of Physiology-Cell Physiology · 64
Modulation of Electron Transport by Metformin in Cardiac Protection: Role of Complex I
2019 · Ahmed A. Mohsin, Michael Maceyka, et al. · The FASEB Journal
Activation of Mitochondrial Calpains Contributes to the Selective Degradation of Specific Mitochondrial Proteins
2019 · Qun Chen, Jeremy Thompson, et al. · The FASEB Journal
Aging‐induced Mitochondrial Damage: The Role of Endoplasmic Reticulum Stress
2019 · Qun Chen, Jeremy Thompson, et al. · The FASEB Journal · 1
Increased Mitochondrial ROS Generation from Complex III Causes Mitochondrial Damage and Increases Endoplasmic Reticulum Stress
2019 · Qun Chen, Jeremy C. Allegood, et al. · The FASEB Journal · 15
Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
2019 · Ahmed A Mohsin, Qun Chen, et al. · Journal of Pharmacology and Experimental Therapeutics · 87
PDF
Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage
2019 · Qun Chen, Jeremy Thompson, et al. · Frontiers in Cardiovascular Medicine · 32
PDF
Cardiac protection by moving the mitochondria?
2018 · Qun Chen, Hema Aluri, et al. · International Journal of Cardiology · 2
Metformin as a modulator of myocardial fibrosis postmyocardial infarction via regulation of cardiomyocyte-fibroblast crosstalk
2018 · Giselle C. Melendez, Qun Chen, et al. · Translational research · 4
A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1
2018 · Qun Chen, Edward J Lesnefsky · Cardiovascular Research · 13
Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion
2017 · Qun Chen, Masood Younus, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 30
Insights into the Impact of a Membrane-Anchoring Moiety on the Biological Activities of Bivalent Compounds As Potential Neuroprotectants for Alzheimer’s Disease
2017 · Liu He, Yuqi Jiang, et al. · Journal of Medicinal Chemistry · 18
The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals
2017 · Yibao Ma, Hae-Ki Min, et al. · Journal of Biological Chemistry · 15
PDF
Metformin attenuates ER stress–induced mitochondrial dysfunction
2017 · Qun Chen, Jeremy Thompson, et al. · Translational research · 87
A New Strategy to Treat Mitochondrial Disease Without Improvement of Mitochondrial Function?
2017 · Qun Chen, Edward J. Lesnefsky · EBioMedicine · 2
Year
Topic