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Diet and Cognition within a Reserve framework

Description: Relevance Mediterranean-type diet has been increasingly identified as playing an important role in preventing Alzheimer’s disease and cognitive decline in the elderly, but the mechanisms remain unclear. Several reserve concepts, including brain reserve, brain maintenance, and cognitive reserve, collectively explain individual differences in cognition, function or clinical status relative to aging and brain disease. In this proposal, using data from two well-established imaging cohorts we will examine the respect roles of brain reserve, brain maintenance, and cognitive reserve in cognitive benefits of Mediterranean-type diet.
Funding type: research
Funder scheme: R01
Start date: 2020-04-01
End date: 2026-02-28
Investigator: YIAN GU
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Field: Medicine
Funded outputs count: 30
Funder award ID: R01AG061008
OpenAlex ID: G2762170527
Plasma phosphorylated tau 181, vascular risk factors, and cognition in elderly Hispanics
2026 · Aanya Bahl, Lawrence S. Honig, et al. · Journal of Alzheimer s Disease · 1
Mixture of organic pollutants is associated with cognitive aging
2026 · Vrinda Kalia, Katherine E. Manz, et al. · Alzheimer s & Dementia · 2
Racial/ethnic differences in the association of lifestyle factors with biological aging in NHANES, 1999-2018
2025 · Talha Arif, Aline Thomas, et al. · The Journals of Gerontology Series A · 2
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Nutrient-Wide Association Study for Dementia Risks: A Prospective Cohort Study in Middle-Aged and Older Adults
2025 · Jing Guo, Yian Gu · Nutrients · 1
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Association of dietary fatty acids with longitudinal change in plasma-based biomarkers of Alzheimer's disease
2025 · Serena S. Hoost, Lawrence S. Honig, et al. · The Journal of Prevention of Alzheimer s Disease · 6
Inflammatory biomarkers profiles and cognition among older adults
2025 · Aline Thomas, Jing Guo, et al. · Scientific Reports · 19
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Physical Activity Moderates the Relationship between Cardiovascular Disease Risk Burden and Cognition in Older Adults
2024 · Sandra T. Nguyen, Jing Guo, et al. · Neuroepidemiology · 2
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Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study
2024 · Aline Thomas, Calen P. Ryan, et al. · Annals of Neurology · 42
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Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
2024 · Alexandra M. Gaynor, Yunglin Gazes, et al. · Neurobiology of Aging · 3
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Cross-sectional and Longitudinal Age-related Disintegration in Functional Connectivity: Reference Ability Neural Network Cohort
2024 · Georgette Argiris, Yaakov Stern, et al. · Journal of Cognitive Neuroscience · 5
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Risk of Alzheimer’s Disease is Associated with Longitudinal Changes in Plasma Biomarkers in the Multiethnic Washington Heights, Inwood Columbia Aging Project Cohort
2023 · Yian Gu, Lawrence S. Honig, et al. · medRxiv · 2
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Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999–2018
2023 · Aline Thomas, Daniel W Belsky, et al. · The Journals of Gerontology Series A · 110
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Longitudinal association between changes in resting-state network connectivity and cognition trajectories: The moderation role of a healthy diet
2023 · Alexandra M. Gaynor, Eleanna Varangis, et al. · Frontiers in Human Neuroscience · 2
Leisure activity engagement across adulthood predicts cognitive change after five years: Do gender and age matter?
2022 · Sharon Sanz Simon, Seonjoo Lee, et al. · Journal of the International Neuropsychological Society · 19
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Physical activity moderates the association between white matter hyperintensity burden and cognitive change
2022 · Suhang Song, Alexandra M. Gaynor, et al. · Frontiers in Aging Neuroscience · 19
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Diet moderates the effect of resting state functional connectivity on cognitive function
2022 · Alexandra M. Gaynor, Eleanna Varangis, et al. · Scientific Reports · 18
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Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults
2022 · Suhang Song, Alexandra M. Gaynor, et al. · Nutrients · 22
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Clinical Trajectories at the End of Life in Autopsy-Confirmed Dementia Patients With Alzheimer Disease and Lewy Bodies Pathologies
2022 · Yian Gu, Anton Kociolek, et al. · Neurology · 23
Aducanumab Use in Symptomatic Alzheimer Disease Evidence in Focus [RETIRED]
2022 · Gregory S. Day, Nikolaos Scarmeas, et al. · Neurology · 40
Association Between Mediterranean Diet and Functional Status in Older Adults: A Longitudinal Study Based on the Washington Heights–Inwood Columbia Aging Project
2022 · Jing Guo, Nicole Schupf, et al. · The Journals of Gerontology Series A · 10
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence
2021 · Suhang Song, Yaakov Stern, et al. · Ageing Research Reviews · 248
Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer’s Disease in a Multiethnic Population
2021 · Yian Gu, Mia Nishikawa, et al. · Current Alzheimer Research · 21
Dietary factors and MRI metrics in early Multiple Sclerosis
2021 · I.B. Katz Sand, Kathryn C. Fitzgerald, et al. · Multiple Sclerosis and Related Disorders · 26
Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype
2021 · Jing Guo, Adam M. Brickman, et al. · Alzheimer s & Dementia · 56
Association Between Early Psychotic Symptoms and Alzheimer’s Disease Prognosis in a Community-Based Cohort
2021 · Reena T. Gottesman, Anton Kociolek, et al. · Journal of Alzheimer s Disease · 6
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