Adipocyte development: lineage analysis and molecular characterization
Description: PUBLIC HEALTH RELEVANCE: The ability to regulate fat storage and metabolism are fundamental processes; however, the dual epidemics of obesity and diabetes endanger millions and are altering our health care landscape. This crisis could be addressed by identifying the cells and genes that control formation and expansion of adipose tissue; we identified the adipose stem cell and found that it is important in the normal maintenance of adipose tissue mass and the response to diabetes treatments. Our goal is to unravel the developmental, physiological and molecular mechanisms underlying these effects, which we believe will enhance our understanding of adipocyte biology and metabolism and may lead to novel therapeutic targets for obesity and diabetes.
Funding type: research
Funder scheme: R01
Start date: 2003-09-15
End date: 2019-03-31
Investigator: JONATHAN M GRAFF
Institution: UT SOUTHWESTERN MEDICAL CENTER
Funded outputs count: 23
Funder award ID: R01DK066556
OpenAlex ID: G5444897328