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Modulators of DNA damage associated nucleo-mitochondrial communication in aging

Description: PUBLIC HEALTH RELEVANCE: The goal of these studies is to identify the molecular mechanism(s) by which stochastic, endogenous nuclear DNA damage leads to oxidative stress and drives cellular senescence and aging. Deciphering these pathways is anticipated to yield novel targets that could be therapeutically targeted to simultaneously prevent progression of numerous age-related degenerative diseases.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R00

Start date: 2017-09-30

End date: 2020-12-31

Investigator: ADITI U GURKAR

Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

Funded outputs count: 19

Funder award ID: R00AG049126

OpenAlex ID: G1814347064

A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans

2024 · Shruthi Hamsanathan, Tamil Anthonymuthu, et al. · Aging Cell · 19

A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions In Vivo

2023 · Suhao Han, Austin Sims, et al. · Genes · 2

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy

2023 · Chathurika Henpita, Rajesh Vyas, et al. · Aging Cell · 29

Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

2022 · Shruthi Hamsanathan, Tamil Anthonymuthu, et al. · Science Advances · 30

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

2021 · Lucile Marchal, Shruthi Hamsanathan, et al. · Mechanisms of Ageing and Development · 3

Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

2021 · Miranda K. Culley, Jingsi Zhao, et al. · Journal of Clinical Investigation · 80

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

2020 · Jing Zhao, Lei Zhang, et al. · Aging · 122

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

2020 · Bryan A Martinez, Pedro Reis Rodrigues, et al. · eLife · 24

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

2020 · Matthew J. Yousefzadeh, Jing Zhao, et al. · Aging Cell · 331

Exonic Variants in Aging-Related Genes Are Predictive of Phenotypic Aging Status

2019 · Megan E. Breitbach, Susan Greenspan, et al. · Frontiers in Genetics · 7

Cellular Senescence: The Trojan Horse in Chronic Lung Diseases

2019 · Shruthi Hamsanathan, Jonathan K. Alder, et al. · American Journal of Respiratory Cell and Molecular Biology · 87

Methods to Quantify the NF-κB Pathway During Senescence

2018 · Lei Zhang, Jing Zhao, et al. · Methods in molecular biology · 18

Nuclear Genomic Instability and Aging

2018 · Laura J. Niedernhofer, Aditi U. Gurkar, et al. · Annual Review of Biochemistry · 275

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

2018 · Aditi U. Gurkar, Andria R. Robinson, et al. · Redox Biology · 43

ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation

2018 · Jolanta Czerwińska, Małgorzata Nowak, et al. · Free Radical Biology and Medicine · 20

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

2018 · Andria R. Robinson, Matthew J. Yousefzadeh, et al. · Redox Biology · 155

Quantitative Analysis of Cellular Senescence in Culture and In Vivo

2017 · Jing Zhao, Heike Fuhrmann‐Stroissnigg, et al. · Current Protocols in Cytometry · 20

Comparison of mice with accelerated aging caused by distinct mechanisms

2015 · Aditi U. Gurkar, Laura J. Niedernhofer · Experimental Gerontology · 70

On the Origin of the Blue Halo Stars

1974 · A. V. Sweigart, J. G. Mengel, et al.