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CA129105

Funded outputs count: 20
Funder award ID: CA129105
OpenAlex ID: G1901769166
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
2025 · Martin S. Taylor, Maggie Chen, et al. · Science · 11
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
2021 · Kendall J. Condon, Jose M. Orozco, et al. · Proceedings of the National Academy of Sciences · 132
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
2020 · Bryan Ngo, Eugenie Kim, et al. · Cancer Discovery · 274
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
2015 · Dohoon Kim, Brian P. Fiske, et al. · Nature · 368
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells
2014 · Walter W. Chen, Kıvanç Birsoy, et al. · Cell Reports · 79
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
2014 · Kıvanç Birsoy, Richard Possemato, et al. · Nature · 710
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
2014 · Brian C. Grabiner, Valentina Nardi, et al. · Cancer Discovery · 455
Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer
2014 · Maria M. Mihaylova, David M. Sabatini, et al. · Cell stem cell · 154
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Nutrients versus growth factors in mTORC1 activation
2013 · Alejo Efeyan, David M. Sabatini · Europe PMC (PubMed Central)
Nutrients and growth factors in mTORC1 activation
2013 · Alejo Efeyan, David M. Sabatini · Biochemical Society Transactions · 60
Young and old genetically heterogeneous HET 3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
2013 · Dudley W. Lamming, Lan Ye, et al. · Aging Cell · 74
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Regulation of mTORC1 and its impact on gene expression at a glance
2013 · Mathieu Laplante, David M. Sabatini · Journal of Cell Science · 668
Cancer Cell Metabolism: One Hallmark, Many Faces
2012 · Jason R. Cantor, David M. Sabatini · Cancer Discovery · 949
DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity
2012 · Mathieu Laplante, Simon Horvat, et al. · Cell Metabolism · 114
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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
2012 · Ömer H. Yilmaz, Pekka Katajisto, et al. · Nature · 753
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
2012 · Stacey Robida-Stubbs, Kira Glover-Cutter, et al. · Cell Metabolism · 648
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A unifying model for mTORC1-mediated regulation of mRNA translation
2012 · Carson C. Thoreen, Lynne Chantranupong, et al. · Nature · 1,477
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
2012 · Dudley W. Lamming, Lan Ye, et al. · Science · 1,199
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin
2011 · Jan H. Reiling, Clary B. Clish, et al. · Proceedings of the National Academy of Sciences · 104
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
2010 · Shomit Sengupta, Timothy R. Peterson, et al. · Nature · 645
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