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Effect of interferon signals in the brain on the induction of systemic aging

Description: Type I interferon (IFN) is a cytokine important for the host antiviral response. On the other hand, it has been reported that IFN, which is non-infectiously expressed in the brain and the periphery, affects the homeostasis and function of the nervous system and may be involved in brain aging and systemic aging. In this study, we attempted to generate a novel mouse model in which IFN signals are chronically activated in the brain. Among them, we established a mouse model capable of constitutively activating the IFN signal with microglia, which is involved in the regulation of neuroinflammation and neurobehavior.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,420,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2018-04-01

End date: 2021-03-31

Investigator: Sato Taku

Institution: Tokyo Medical and Dental University

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences