In vivo real time detection of circulating melanoma cells
Description: PUBLIC HEALTH RELEVANCE: The capability of a painless, noninvasive, labeling-free, photoacoustic flow cytometry for selective, time-resolved detection of photoacoustic signals from different vessels will be assessed in (1) white and black healthy volunteers and (2) melanoma patients at different stages of disease, in whom circulating metastatic melanoma cells will be quantitatively determined. In the course of this study, we will obtain statistically significant data that will demonstrate this innovative technique's unprecedented capability for quantitatively monitoring circulating melanoma cells in vivo without the need for labeling. The benefits to the public health of achieving this goal extend to the routine monitoring of circulatin cells as early markers of micrometastatic development and cancer recurrence in vivo in melanoma patients, as well as to evaluating the efficacy of therapy.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2007-12-01
End date: 2022-03-31
Investigator: JAMES SUEN
Institution: UNIV OF ARKANSAS FOR MED SCIS
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Funded outputs count: 88
Funder award ID: R01CA131164
OpenAlex ID: G2606785268