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Emotion-cognition interactions and aging

Description: PROJECT NARRATIVE Recent findings indicate that the locus coeruleus is the first place in the brain that Alzheimer’s disease pathology is found and that nearly all adults have at least some disease-related pathology there by age 40. Post-mortem neuron density in the locus coeruleus is also one of the strongest brain predictors of cognitive decline, yet little is known about how function in this region changes with age and disease. In this project, we examine relationships between the locus coeruleus and attention and memory processes in aging and in Alzheimer’s disease.
Funding type: research
Funder scheme: R01
Start date: 2004-09-01
End date: 2023-02-28
Investigator: MARA MATHER
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Funded outputs count: 132
Funder award ID: R01AG025340
OpenAlex ID: G8849727358
About time? The role of time perspective in the priority for positive over negative emotion in attention
2026 · Briana L. Kennedy, Mara Mather · Cognition & Emotion
Locus coeruleus-related insula activation is associated with implicit learning
2025 · Martin J. Dahl, Tiantian Li, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 4
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Negative images, regardless of task relevance, distract younger more than older adults.
2024 · Briana L. Kennedy, Mara Mather · Psychology and Aging · 10
The emotion paradox in the aging body and brain
2024 · Mara Mather · Annals of the New York Academy of Sciences · 36
Short-term blood pressure variability and brain functional network connectivity in older adults
2024 · Isabel J. Sible, Jung Yun Jang, et al. · Neuroimage Reports · 6
The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
2023 · Martin J. Dahl, Shelby L. Bachman, et al. · Nature Aging · 73
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Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer’s disease
2023 · Martin J. Dahl, Agnieszka Kulesza, et al. · Neuroscience & Biobehavioral Reviews · 63
Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice
2023 · Victor Bodart‐Santos, Lisandra S. Pinheiro, et al. · Alzheimer s & Dementia · 38
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Isometric handgrip exercise speeds working memory responses in younger and older adults.
2023 · Shelby L. Bachman, Sumedha Attanti, et al. · Psychology and Aging · 9
Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
2023 · Alexander J. Ehrenberg, Michael A. Kelberman, et al. · Alzheimer s & Dementia · 72
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Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults
2023 · Isabel J. Sible, Hyun Joo Yoo, et al. · Aging Brain · 3
The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
2022 · Martin J. Dahl, Shelby L. Bachman, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7
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Behavioral and fMRI evidence that arousal enhances bottom-up selectivity in young but not older adults
2022 · Sara N. Gallant, Briana L. Kennedy, et al. · Neurobiology of Aging · 16
Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease
2022 · Jonathan Vöglein, Nicolai Franzmeier, et al. · Alzheimer s & Dementia · 10
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Effects of acute exercise on emotional memory
2022 · Paul Loprinzi, Danielle Olafson, et al. · Cognition & Emotion · 8
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Associations between locus coeruleus MRI contrast and physiological responses to acute stress in younger and older adults
2022 · Shelby L. Bachman, Kaoru Nashiro, et al. · Brain Research · 16
Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract
2022 · Shai Porat, Francesca Sibilia, et al. · NeuroImage · 15
Mental imagery can generate and regulate acquired differential fear conditioned reactivity
2022 · Steven G. Greening, Tae-Ho Lee, et al. · Scientific Reports · 31
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Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease
2021 · Martin J. Dahl, Mara Mather, et al. · Neurobiology of Aging · 147
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Noradrenergic modulation of rhythmic neural activity shapes selective attention
2021 · Martin J. Dahl, Mara Mather, et al. · Trends in Cognitive Sciences · 158
Behavioral and fMRI evidence that arousal enhances bottom-up attention and memory selectivity in young but not older adults
2021 · Sara N. Gallant, Briana L. Kennedy, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?
2021 · Mara Mather · Seminars in Cell and Developmental Biology · 52
Aging and the nervous system
2021 · Mara Mather · Seminars in Cell and Developmental Biology · 3
Age-differences in interpreting the valence of ambiguous facial expressions: evidence for multiple contributing processes
2021 · Sarah J. Barber, Andrej Schoeke, et al. · Aging Neuropsychology and Cognition · 5
Brainstem substructures and cognition in prodromal Alzheimer’s disease
2021 · Shubir Dutt, Yanrong Li, et al. · Brain Imaging and Behavior · 36
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