Synergistic role of signaling and epigenetics in leukemic transformation
Description: PROJECT NARRATIVE We will use studies in patient samples and in innovative preclinical models to delineate how clonal evolution contributes to malignancy and to the response to cancer therapies. We will model clonal evolution using novel in vivo preclinical models and perform functional studies to delineate the key networks and targets which govern malignancy. This work will delineate how mutational evolution contributes to cancer initiation and progression and use these insights to identify novel therapeutic targets which can intercept/prevent or attenuate malignancy.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R35
Start date: 2017-01-17
End date: 2030-07-31
Investigator: ROSS L LEVINE
Institution: SLOAN-KETTERING INST CAN RESEARCH
Funded outputs count: 73
Funder award ID: R35CA197594
OpenAlex ID: G9000895359