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P53 and Organismal Aging

Funding type: research
Funder scheme: R01
Start date: 2002-09-15
End date: 2008-08-31
Investigator: LAWRENCE A. DONEHOWER
Institution: BAYLOR COLLEGE OF MEDICINE
Funded outputs count: 6
Funder award ID: R01AG019693
OpenAlex ID: G421628845
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
2009 · George W. Hinkal, Catherine E. Gatza, et al. · Mechanisms of Ageing and Development · 45
How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
2008 · George Hinkal, Lawrence A. Donehower · Mechanisms of Ageing and Development · 34
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
2007 · Lynette Moore, Xiongbin Lu, et al. · Mechanisms of Ageing and Development · 39
Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
2007 · Catherine E. Gatza, Melissa Dumble, et al. · Developmental Biology · 31
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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
2007 · Stuart M Chambers, Chad A Shaw, et al. · PLoS Biology · 799
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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
2006 · Melissa Dumble, Lynette Moore, et al. · Blood · 241
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