Effect of maternal diet-induced obesity on postnatal allergy
Description: This study analyzed the effect of a maternal diet induced obesity (DIO) on aging process in offspring. The body weights in offspring from dam exposed to a high-fat (HF)diet were significantly higher in the early stage of life but then became lower in the later stage of life. The week the mice reached their maximum body weight was earlier in offspring from dam exposed a HF diet. Regarding immunological parameters, senescence-associated T cells were increased, and natural killer T cells were decreased by the effect of both maternal and offspring HF diet. The effect of maternal HF diet on the OVA-specific IgG and IgE titers were not observed. Non -alcoholic fatty liver disease was much more severe in offspring from dam exposed to a HF diet. In particular, lobular inflammation and fibrosis were prominent by the effect of offspring HF diet. These results suggest that a maternal DIO may accelerate aging process and influence on inflammatory pathophysiology in offspring.
Amount: ¥3,380,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Atsuko IMAI
Institution: Japan Women's University
Funded outputs count: 2
Funder award ID: 16K16290
OpenAlex ID: G1959729909