Investigation of in vivo function of mesenchymal blood cells on maintenance of cutaneous homeostasis and application for therapeutics
Description: In the 3 year study, we clarified that mesenchymal blood cells (MBCs) accumulated into the injured skin to differentiate into the epidermal and follicular keratinocytes, melanocytes, dermal fibroblasts, and peripheral nerves, in which the TGF-b secreting abnormal myelin formation was suppressed not to induce scar formation. Moreover, MBC was shown to be originated from ectomesenchyme, which generate by delamination of neural crest epithelia, indicating developmental identity of the MBCs for regenerating ectodermal epithelia. HMGB1 peptide induced increase of the ectodermal MBCs, suggesting future therapeutic activity of the peptide to regulate cutaneous homeostasis in various skin diseases.
Amount: ¥17,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Katsuto Tamai
Institution: Osaka University
Funded outputs count: 7
Funder award ID: 16H05369
OpenAlex ID: G197143793