Oncogenetic process by the complexed system due to heterochromatin-derived RNA
Description: By focusing the expression of repetitive RNA from heterochromatin region from the early stage of pancreatic cancer, its biological function was examined. Repetitive RNA expression resulted in the accumulation of DNA damages and chromosomal instability through binding with YBX-1 protein. By detecting the repetitive RNA from the patinets’ sera, this may be a novel biomarker for the detection of early pancreatic cancer. In addition, we newly identified a novel circular RNA expressing specifically in pancreatic cancer and its expression in the tissues were examined. Through the analyses of complexed system involving DNA, RNA, and protein, clinically useful biomarkers can be developed.
Amount: ¥18,590,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-07-19
End date: 2019-03-31
Investigator: Motoyuki OTSUKA
Institution: The University of Tokyo
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 9
Funder award ID: 16KT0109
OpenAlex ID: G1996374101