Development of objective indicators for elderly patients receiving chemotherapy.
Description: We prospectively enrolled malignant lymphoma patients aged 65 years or older undergoing first-line chemotherapy at two institutions from December 2017 to June 2020, and investigated clinical information including iliopsoas muscle volume and laboratory data (albumin, creatinine, cystatin C). In addition, CGA questionnaires were conducted. <RESULTS>Sixty patients were enrolled, median age 74 years (range, 65-86ears). Factors contributing to event-free survival were analyzed using treatment interruption or death as an event. Univariate analysis showed significant differences in eGFRcr-eGFRcys, serum albumin, and PS0, but not in muscle mass or CGA score. The present study suggests that the eGFRcr-eGFRcys values, which can be easily measured before treatment, may be useful for evaluating frailty, although it was conducted in a small number of patients.
Amount: ¥2,470,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Makiko Takizawa
Institution: Gunma University
Funded outputs count: 7
Funder award ID: 17K09225
OpenAlex ID: G2000864368