Award

BubRI in Cancer and Aging

Description: NARRATIVE The proposed research is relevant to public health because it is expected to fundamentally advance our mech- anistic understanding of a multifunctional mitotic regulator, BubR1, that is implicated in two major human health problems, cancer and aging. We expect this knowledge to pave the way towards transformative clinical inter- ventions for treating or preventing a broad spectrum of human cancers and age-related diseases that limit healthspan.

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2002-07-01

End date: 2024-06-30

Investigator: DARREN BAKER

Institution: MAYO CLINIC ROCHESTER

Funded outputs count: 58

Funder award ID: R01CA096985

OpenAlex ID: G8623854477

Senescent cells limit p53 activity via multiple mechanisms to remain viable

2022 · Ines Sturmlechner, Chance C. Sine, et al. · Nature Communications · 45

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

2021 · Ines Sturmlechner, Cheng Zhang, et al. · Science · 294

Cellular Stress in Aging and Cancer

2021 · Ines Sturmlechner

FoxM1 insufficiency hyperactivates Ect2–RhoA–mDia1 signaling to drive cancer

2020 · Jazeel F. Limzerwala, Karthik B. Jeganathan, et al. · Nature Cancer · 14

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

2020 · Eva Moreno, Mathilda J.M. Toussaint, et al. · Hepatology · 37

Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication

2020 · Zhuang Wei, Tae-Sung Kim, et al. · Molecular and Cellular Biology · 35

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

2019 · Cynthia J. Sieben, Karthik B. Jeganathan, et al. · Journal of Clinical Investigation · 30

Senolytic therapies for healthy longevity

2019 · Jan M. van Deursen · Science · 237

Senescent cells in the development of cardiometabolic disease

2019 · Andrea C. Postmus, Ines Sturmlechner, et al. · Current Opinion in Lipidology · 10

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

2019 · Khaled Aziz, Jazeel F. Limzerwala, et al. · Gastroenterology · 71

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

2018 · Khaled Aziz, Cynthia J. Sieben, et al. · Journal of Clinical Investigation · 27

Two-Step Senescence-Focused Cancer Therapies

2018 · Cynthia J. Sieben, Ines Sturmlechner, et al. · Trends in Cell Biology · 222

Senescent cells: a therapeutic target for cardiovascular disease

2018 · Bennett G. Childs, Hu Li, et al. · Journal of Clinical Investigation · 192

Senescent cells: an emerging target for diseases of ageing

2017 · Bennett G. Childs, Martina Gluscevic, et al. · Nature Reviews Drug Discovery · 1,284

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

2017 · Ok Hee Jeon, Chaekyu Kim, et al. · Nature Medicine · 1,515

Singling Out Chromosome Gains in Tumor Evolution

2017 · Ryan M. Naylor, Jan M. van Deursen · Cancer Cell

Aneuploidy in Cancer and Aging

2016 · Ryan M. Naylor, Jan M. van Deursen · Annual Review of Genetics · 65

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

2016 · Bennett G. Childs, Darren J. Baker, et al. · Science · 1,191

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

2016 · Robbyn L Weaver, Jazeel F Limzerwala, et al. · eLife · 20

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

2016 · Marissa J. Schafer, Thomas A. White, et al. · Diabetes · 267

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

2016 · Yu Yamazaki, Darren J. Baker, et al. · Stroke · 263

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

2016 · Darren J. Baker, Bennett G. Childs, et al. · Nature · 2,809

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

2016 · Ryan M. Naylor, Karthik B. Jeganathan, et al. · Journal of Clinical Investigation · 40

Translational strategies in aging and age-related disease

2015 · Mary Armanios, Rafael de Cabo, et al. · Nature Medicine · 36

Cellular senescence in aging and age-related disease: from mechanisms to therapy

2015 · Bennett G Childs, Matej Durik, et al. · Nature Medicine · 2,359