Elucidation of the mechanism of HMGA2-induced transition of neural stem cells from expansion to neurogenic phase
Description: Most of the neurons, the most important cell types in the brain, are produced from neural stem cells during development. In the early stages of development, neural stem cells increase their number by self-renewal, but at a certain point, they begin to produce neurons. The timing of this fate change should be strictly regulated because it determines the number of neurons that are subsequently produced. However, the regulatory mechanism has been unknown. In this study, we found that the upregulation of Hmga2, a chromatin-regulating factor, during the transition from expansion to neurogenic phases regulates the gene expression pattern of neural stem cells and promotes fate switching.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Yusuke Kishi
Institution: The University of Tokyo
Funded outputs count: 12
Funder award ID: 18K14622
OpenAlex ID: G2014294588