Get started
Award

EY 07099

Funded outputs count: 63
Funder award ID: EY 07099
OpenAlex ID: G201488848
Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases
2020 · Xingjun Fan, David R. Sell, et al. · Aging Cell · 25
PDF
Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration
2017 · Weiyi Feng, Mariana Rosca, et al. · Human Molecular Genetics · 34
PDF
Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches
2016 · Xingjun Fan, Vincent M. Monnier, et al. · Experimental Eye Research · 84
The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes
2016 · Vincent M. Monnier, Saul Genuth, et al. · Glycoconjugate Journal · 38
Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes
2016 · David R. Sell, Wanjie Sun, et al. · Cardiovascular Diabetology · 24
PDF
Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens*
2015 · Xingjun Fan, Sheng Zhou, et al. · Molecular & Cellular Proteomics · 51
Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness
2014 · Gion Fessel, Yufei Li, et al. · PLoS ONE · 152
PDF
UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products
2014 · Mikhail Linetsky, Cibin T. Raghavan, et al. · Journal of Biological Chemistry · 71
Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications
2013 · Vincent M. Monnier, Wanjie Sun, et al. · Clinical Chemistry and Laboratory Medicine (CCLM) · 72
PDF
The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis
2012 · Xingjun Fan, Xiaoqin Liu, et al. · PLoS ONE · 40
PDF
Oxygen Reactivity in Flavoenzymes: Context Matters
2011 · Claudia A. McDonald, Rebecca L. Fagan, et al. · Journal of the American Chemical Society · 75
Vitamin C Degradation Products and Pathways in the Human Lens
2011 · Ina Nemet, Vincent M. Monnier · Journal of Biological Chemistry · 84
PDF
The Cation−π Interaction between Lys53 and the Flavin of Fructosamine Oxidase (FAOX-II) Is Critical for Activity
2011 · François Collard, Rebecca L. Fagan, et al. · Biochemistry · 11
Favored and disfavored pathways of protein crosslinking by glucose: glucose lysine dimer (GLUCOLD) and crossline versus glucosepane
2010 · Ina Nemet, Christopher M. Strauch, et al. · Amino Acids · 23
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis
2010 · Xingjun Fan, David R. Sell, et al. · Free Radical Biology and Medicine · 70
Mechanism of Lysine Oxidation in Human Lens Crystallins during Aging and in Diabetes
2009 · Xingjun Fan, Jianye Zhang, et al. · Journal of Biological Chemistry · 62
PDF
Inhibition of Crystallin Ascorbylation by Nucleophilic Compounds in the hSVCT2 Mouse Model of Lenticular Aging
2008 · Xingjun Fan, Vincent M. Monnier · Investigative Ophthalmology & Visual Science · 19
Crystal Structure of the Deglycating Enzyme Fructosamine Oxidase (Amadoriase II)
2008 · François Collard, Jianye Zhang, et al. · Journal of Biological Chemistry · 57
PDF
Identification of Glucose-Derived Cross-Linking Sites in Ribonuclease A
2008 · Zhenyu Dai, Benlian Wang, et al. · Journal of Proteome Research · 32
Isolation, purification and characterization of histidino-threosidine, a novel Maillard reaction protein crosslink from threose, lysine and histidine
2007 · Zhenyu Dai, Ina Nemet, et al. · Archives of Biochemistry and Biophysics · 19
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model
2006 · Xingjun Fan, Lixing W. Reneker, et al. · Proceedings of the National Academy of Sciences · 113
Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells
2006 · Mark E. Obrenovich, Xingjun Fan, et al. · Molecular and Cellular Biochemistry · 8
Ornithine Is a Novel Amino Acid and a Marker of Arginine Damage by Oxoaldehydes in Senescent Proteins
2005 · DAVID R. SELL, VINCENT M. MONNIER · Annals of the New York Academy of Sciences · 25
Conversion of Arginine into Ornithine by Advanced Glycation in Senescent Human Collagen and Lens Crystallins
2004 · David R. Sell, Vincent M. Monnier · Journal of Biological Chemistry · 65
PDF
Vitamin C Metabolomic Mapping in the Lens with 6-Deoxy-6-fluoro-ascorbic Acid and High-Resolution 19 F-NMR Spectroscopy
2003 · Makoto Satake, Barbara Dmochowska, et al. · Investigative Ophthalmology & Visual Science · 21
Year
Topic