Deficiency of novel testis-specific intercellular binding KIAA1210 and analysis of transgenic mice expressed fluorescent protein
Description: Intercellular connections are essential for spermatogenesis, and deficiency of them leads to male infertility. These cell-cell junctions include the intercellular bridge (ICB) which formed between germ cells, the blood-testis barrier (BTB) which formed between Sertoli cells, and the Ectoplasmic specialization (ES) which formed between Sertoli cells and elongating spermatids. These cell-cell junctions are expected to have a role in cell-cell communication and germ cell synchronization, etc., but their functions still remain to be elucidated. Usually, these cell-cell junctions are studied individually, but in this study, we focused on KIAA1210 and structurally and functionally analyzed the relationship between cell-cell junctions in the spermatogenesis. Through analyses of KIAA1210 knockout mice as well as knock-in mice in which a fluorescent protein were fused with an intercellular bridge protein, we have published new findings obtained from the preparatory experiments.
Amount: ¥4,420,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Tokuko Iwamori
Institution: Kyushu University
Funded outputs count: 8
Funder award ID: 17K15396
OpenAlex ID: G206101674