Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and Cognition
Description: The impact of our investigation is in the identification of blood biomarkers that reflect the cumulative biological effects of adverse exposures and can be used to predict future cognitive deficits. As the age of the US population increases, mitochondriomic analyses that can be non-invasively conducted on blood samples have the potential to lead to the development of easy-to-measure biomarkers that may help to protect millions of individuals against impaired cognition and its sequelae. By studying the progression of cognitive decline over two decades in a large number of individuals, our research may provide new tools to develop targeted prevention when it is most effective, i.e. in early stages or even before any subclinical cognitive impairment is detected.
Funding type: research
Funder scheme: R01
Start date: 2012-08-20
End date: 2019-04-30
Investigator: ANDREA BACCARELLI
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Funded outputs count: 102
Funder award ID: R01ES021733
OpenAlex ID: G5159444278