Development of small-diameter regenerative long vascular grafts applicable to lower limb arterial bypass
Description: The aim of this study was development of small diameter and long length vascular graft which can bypass between lower limb. In vivo tissue-architecture technology (iBTA) is a technique in which a mold is implanted into a qutaneous pouche to prepare a tissue body made of autologous tissue for implantation in a living body of a patient. In order to prepare the Biotube, which is a tubular tissue that can be fabricated using iBTA technology, into a size that meets the purpose of this study, we made the mold into a compact spiral shape, which is novel design, and made it possible to fabricate Biotubes with a maximum length of 50 cm. In addition, in vivo evaluation of the 25 cm length of Biotube bypassed between arteries showed that the Biotube was able to withstand arterial pressure and functioned as a vascular graft.
Amount: ¥4,290,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Maya Furukoshi
Institution: Osaka Prefecture University
Funded outputs count: 2
Funder award ID: 18K16293
OpenAlex ID: G2097544102